FB2024_03 , released June 25, 2024
Allele: Dmel\corolla1
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General Information
Symbol
Dmel\corolla1
Species
D. melanogaster
Name
FlyBase ID
FBal0284453
Feature type
allele
Associated gene
Dmel\corolla
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Collins et al., 2014)
Mutagen
ethyl methanesulfonate
(Collins et al., 2012)
Progenitor genotype
Cytology
Description

Nucleotide substitution: A2759T.

(Collins et al., 2014)

Amino acid replacement: ?173term.

(Collins et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:17,631,262..17,631,262 [-]
Nucleotide change:

A17631262T

Reported nucleotide change:

A2759T

Amino acid change:

R173term | corolla-PA; R171term | corolla-PB

Reported amino acid change:

?173term

(Collins et al., 2014)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      corolla1 females show frequent meiotic chromosome segregation errors, as assessed by X-chromosome non-disjunction.

      (Lake et al., 2019)

      corolla1, corolla1/corollad01774, corolla1/Df(1)BSC643 and corolla1/Df(1)BSC583 mutants exhibit elevated levels of X and 4th meiotic chromosome nondisjunction.

      Synaptonemal complex formation is completely abolished in corolla1 mutants.

      corolla1 oocytes show a strong defect in centromere clustering and centromere pairing.

      corolla1 oocytes show a reduced number of double-strand breaks compared to controls (all assayed in a okrAA/okrRU background.

      corolla1 mutants show no recombination throughout most of the euchromatin and exhibit a reduced frequency of recombination in the centromere-proximal region.

      (Collins et al., 2014)

      Homozygous females show 42.2% X chromosome nondisjunction and 33.4% 4th chromosome nondisjunction.

      (Collins et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      corolla1 is rescued by corolla+tCa

      (Collins et al., 2014)
      Comments

      corolla+tCa fully suppresses the meiotic nondisjunction phenotype and defective synaptonemal complex seen in corolla1 mutants.

      (Collins et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      corolla1
      (Lake et al., 2019)
      mei-391
      (Collins et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)