FB2024_03 , released June 25, 2024
Allele: Dmel\ktub115-4
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General Information
Symbol
Dmel\ktub115-4
Species
D. melanogaster
Name
FlyBase ID
FBal0284384
Feature type
allele
Associated gene
Dmel\ktub
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Chen et al., 2012)
Mutagen
Delta2-3 transposase
(Chen et al., 2012)
Progenitor genotype
P{GSV6}ktubGS17325
(Chen et al., 2012)
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in a 1.6kb deletion that removes the ATG translation start site of the long ktub isoform.

(Chen et al., 2012)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Photoreceptor cells R1-R6 undergo light-dependent retinal degeneration in mutant flies, while photoreceptor cell R7 is not affected. After 6 days in constant light, the mutant R1-R6 rhabdomeres have short microvilli and the plasma membrane at the base of the rhabdomere appears as a catacomb-like extracellular space.

      (Chen et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      ktub115-4 has abnormal neuroanatomy | conditional phenotype, suppressible by norpAP12

      (Chen et al., 2012)
      Suppressor of
      Statement
      Reference

      ktub115-4 is a suppressor of abnormal neuroanatomy | conditional phenotype of norpAP12

      (Chen et al., 2012)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      ktub115-4 has eye photoreceptor cell | conditional phenotype, suppressible by norpAP12

      (Chen et al., 2012)
      Suppressor of
      Statement
      Reference

      ktub115-4 is a suppressor of eye photoreceptor cell | conditional phenotype of norpAP12

      (Chen et al., 2012)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      norpA33 ; ktub115-4 double mutants have almost normal photoreceptor organisation after 6 days in constant light.

      (Chen et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ktub115-4
      (Chen et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)