FlyBase Allele Report: Hsim\VP16[AD.ac]

General Information

Symbol

Hsim\VP16^AD.ac

Species

S. Herpes simplex virus Type 1

Name

FlyBase ID

FBal0284203

Feature type

allele

Associated gene

Hsim\VP16

Associated Insertion(s)

Carried in Construct

P{ac-VP16.AD}

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Kohwi et al., 2013)

Progenitor genotype

Carried in construct

P{ac-VP16.AD}

Cytology

Description

ac enhancer sequences regulate expression of a VP16(AD)::Zip+ hemidriver (component of a 'split driver' system, contains the VP16 activation domain).

(Kohwi et al., 2013)

Allele components

Component

Use(s)

Regulatory region(s)

Encoded product / tool

VP16(AD)::Zip+

split driver - transcription activation fragment

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell number, with HGTX^HMJ22909, Scer\GAL4^DBD.gsb, Scer\GAL4^KZip+.R25A05

(Seroka et al., 2020)

abnormal cell number, with HGTX^UAS.cBa, Scer\GAL4^DBD.gsb, Scer\GAL4^KZip+.R25A05

(Seroka et al., 2020)

abnormal neuroanatomy, with HGTX^HMJ22909, Scer\GAL4^DBD.gsb, Scer\GAL4^KZip+.R25A05

(Seroka et al., 2020)

abnormal neuroanatomy, with HGTX^UAS.cBa, Scer\GAL4^DBD.gsb, Scer\GAL4^KZip+.R25A05

(Seroka et al., 2020)

abnormal neuroanatomy | first instar larval stage, with Scer\GAL4^DBD.gsb, Scer\GAL4^KZip+.R25A05, hb^UAS.cWa

(Seroka and Doe, 2019)

abnormal neuroanatomy | somatic clone - tissue specific, with HGTX^UAS.cBa, Scer\GAL4^DBD.gsb, Scer\GAL4^KZip+.R25A05

(Seroka et al., 2020)

increased cell number | first instar larval stage, with Scer\GAL4^DBD.gsb, Scer\GAL4^KZip+.R25A05, hb^UAS.cWa

(Seroka and Doe, 2019)

increased cell number | somatic clone - tissue specific, with HGTX^UAS.cBa, Scer\GAL4^DBD.gsb, Scer\GAL4^KZip+.R25A05

(Seroka et al., 2020)

Phenotype Manifest In

embryonic/larval neuromuscular junction | first instar larval stage, with Scer\GAL4^DBD.gsb, Scer\GAL4^KZip+.R25A05, hb^UAS.cWa

(Seroka and Doe, 2019)

lineage NB7-1 primary motor neuron | first instar larval stage, with Scer\GAL4^DBD.gsb, Scer\GAL4^KZip+.R25A05, hb^UAS.cWa

(Seroka and Doe, 2019)

motor neuron, with HGTX^HMJ22909, Scer\GAL4^DBD.gsb, Scer\GAL4^KZip+.R25A05

(Seroka et al., 2020)

motor neuron, with HGTX^UAS.cBa, Scer\GAL4^DBD.gsb, Scer\GAL4^KZip+.R25A05

(Seroka et al., 2020)

motor neuron | increased number | somatic clone - tissue specific, with HGTX^UAS.cBa, Scer\GAL4^DBD.gsb, Scer\GAL4^KZip+.R25A05

(Seroka et al., 2020)

muscle cell of dorsal oblique muscle 1 | first instar larval stage, with Scer\GAL4^DBD.gsb, Scer\GAL4^KZip+.R25A05, hb^UAS.cWa

(Seroka and Doe, 2019)

muscle cell of dorsal oblique muscle 2 | first instar larval stage, with Scer\GAL4^DBD.gsb, Scer\GAL4^KZip+.R25A05, hb^UAS.cWa

(Seroka and Doe, 2019)

muscle cell of lateral longitudinal muscle 1 | first instar larval stage, with Scer\GAL4^DBD.gsb, Scer\GAL4^KZip+.R25A05, hb^UAS.cWa

(Seroka and Doe, 2019)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Phenotype Manifest In

Other

Statement

Reference

Hsim\VP16^AD.ac, Kr^UAS.cHa, Scer\GAL4^DBD.gsb, Scer\GAL4^KZip+.R25A05, pdm2^UAS.Tag:HA has motor neuron phenotype

(Seroka et al., 2020)

Hsim\VP16^AD.ac, Kr^UAS.cHa, Scer\GAL4^DBD.gsb, Scer\GAL4^KZip+.R25A05, pdm2^UAS.Tag:HA has motor neuron | increased number | somatic clone - tissue specific phenotype

(Seroka et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

"Split GAL4" system construct.

(Kohwi et al., 2013)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Hsim\VP16^{AD.ac.T:Zzzz\Zip+}

Hsim\VP16^{AD.ac.T:Zzzz\ZipEERRL}

Hsim\VP16^AD.ac

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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