FB2024_03 , released June 25, 2024
Allele: Hsap\MTMR4UAS.cYa
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General Information
Symbol
Hsap\MTMR4UAS.cYa
Species
H. sapiens
Name
Saccharomyces cerevisiae UAS construct a of Yu
FlyBase ID
FBal0283049
Feature type
allele
Associated gene
Hsap\MTMR4
Associated Insertion(s)
Carried in Construct
P{UAS-MTMR4.Y}
Key Links
Transgenic product class
wild_type
(Yu et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Yu et al., 2013)
Mutagen
in vitro construct
(Yu et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-MTMR4.Y}
Cytology
Description

UAS regulatory sequences drive expression of Hsap\MTMR4.

(Yu et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\MTMR4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing Hsap\MTMR4Scer\UAS.cYa under the control of Scer\GAL4vg.PM sometimes show branches at the posterior crossvein.

      (Yu et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      Hsap\MTMR4UAS.cYa, Scer\GAL4vg.PM has visible phenotype, enhanceable by tkvRNAi.UAS.cUa, Scer\GAL4vg.PM

      (Yu et al., 2013)
      Enhancer of
      Statement
      Reference

      Hsap\MTMR4UAS.cYa, Scer\GAL4vg.PM is an enhancer of visible phenotype of Scer\GAL4vg.PM, tkvRNAi.UAS.cUa

      (Yu et al., 2013)
      Suppressor of
      Statement
      Reference

      Hsap\MTMR4UAS.cYa, Scer\GAL4vg.PM is a suppressor | partially of visible phenotype of Scer\GAL4vg.PM, gbbUAS.cUa

      (Yu et al., 2013)
      Phenotype Manifest In
      Enhanced by
      Enhancer of
      Statement
      Reference

      Hsap\MTMR4UAS.cYa, Scer\GAL4vg.PM is an enhancer of wing vein | ectopic phenotype of Scer\GAL4vg.PM, tkvRNAi.UAS.cUa

      (Yu et al., 2013)
      Suppressor of
      Statement
      Reference

      Hsap\MTMR4UAS.cYa, Scer\GAL4vg.PM is a suppressor | partially of wing vein | ectopic phenotype of Scer\GAL4vg.PM, gbbUAS.cUa

      (Yu et al., 2013)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of Hsap\MTMR4Scer\UAS.cYa and tkvdsRNA.Scer\UAS.cUa under the control of Scer\GAL4vg.PM enhances the penetrance of the branched posterior crossvein phenotype compared to when each is expressed alone. In addition, more severe vein defects are seen, with partial duplications and gaps.

      Co-expression of Hsap\MTMR4Scer\UAS.cYa partially suppresses the ectopic wing vein formation seen in flies expressing gbbScer\UAS.cUa under the control of Scer\GAL4vg.PM.

      (Yu et al., 2013)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsap\MTMR4Scer\UAS.cYa
      Hsap\MTMR4UAS.cYa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Yu
      Secondary FlyBase IDs
        References (1)