FB2024_03 , released June 25, 2024
Allele: Dmel\tkvRNAi.UAS.cUa
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General Information
Symbol
Dmel\tkvRNAi.UAS.cUa
Species
D. melanogaster
Name
FlyBase ID
FBal0283048
Feature type
allele
Associated gene
Dmel\tkv
Associated Insertion(s)
Carried in Construct
P{UAS-tkv.RNAi.U}
Key Links
Transgenic product class
RNAi_reagent
(Yu et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Yu et al., 2013)
Mutagen
in vitro construct
(Yu et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-tkv.RNAi.U}
Cytology
Description

UAS regulatory sequences drive expression of a tkv RNAi construct.

(Yu et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
tkv
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The embryonic midgut of individuals expressing tkvdsRNA.Scer\UAS.cUa under the control of Scer\GAL4Mef2.PU lacks the prominent second constriction normally observed in controls.

      (Galeone et al., 2017)

      Wing defects are apparent upon expression of Scer\GAL4C-765>tkvdsRNA.Scer\UAS.cUa, including enlargement of wing size in addition to ectopic veins.

      (Chauhan et al., 2013)

      Flies expressing tkvdsRNA.Scer\UAS.cUa under the control of Scer\GAL4vg.PM often show branches at the posterior crossvein.

      (Yu et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Suppressed by
      Statement
      Reference

      Scer\GAL4C-765, tkvRNAi.UAS.cUa has visible phenotype, suppressible | partially by LptRNAi.UAS, Scer\GAL4C-765

      (Chauhan et al., 2013)
      Enhancer of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Simultaneous expression of tkvdsRNA.Scer\UAS.cUa and LptdsRNA.Scer\UAS under the control of Scer\GAL4C-765 suppresses the tkvdsRNA.Scer\UAS.cUa phenotypes.

      Co-expression of LptScer\UAS.T:Ivir\HA1 and tkvdsRNA.Scer\UAS.cUa under the control of Scer\GAL4C-765 results in an enhancement of the tkvdsRNA.Scer\UAS.cUa phenotypes.

      (Chauhan et al., 2013)

      Co-expression of CG3632Scer\UAS.cYa and tkvdsRNA.Scer\UAS.cUa under the control of Scer\GAL4vg.PM enhances the penetrance of the branched posterior crossvein phenotype compared to when each is expressed alone. In addition, more severe vein defects are seen, with partial duplications and gaps.

      (Yu et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of Hsap\MTMR4Scer\UAS.cYa and tkvdsRNA.Scer\UAS.cUa under the control of Scer\GAL4vg.PM enhances the penetrance of the branched posterior crossvein phenotype compared to when each is expressed alone. In addition, more severe vein defects are seen, with partial duplications and gaps.

      (Yu et al., 2013)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      tkvRNAi.UAS.cUa
      tkvRNAi
      (Inaba et al., 2015)
      tkvRi
      (Lodge et al., 2021)
      tkvdsRNA.Scer\UAS.cUa
      tkvdsRNA.UAS.cUa
      Name Synonyms
      Secondary FlyBase IDs
        References (7)