FlyBase Allele Report: Dmel\N[5XUAS.JF01356]

General Information

Symbol

Dmel\N^{5XUAS.JF01356}

Species

D. melanogaster

Name

FlyBase ID

FBal0282542

Feature type

allele

Associated gene

Dmel\N

Associated Insertion(s)

Carried in Construct

P{TRiP.JF01356.5XUAS}

Key Links

Transgenic product class

Mutagen

cre recombinase

Nature of the Allele

Transgenic product class

Mutagen

cre recombinase

(Ni et al., 2008)

Progenitor genotype

N^JF01356

(Ni et al., 2008)

Carried in construct

P{TRiP.JF01356.5XUAS}

Cytology

Description

One of the two UAS pentameters in N^JF01356 has been excised using P1\cre.

(Ni et al., 2008)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell number | larval stage, with Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

visible | adult stage, with Scer\GAL4^bbg-C96

(Ni et al., 2008)

Phenotype Manifest In

embryonic/larval brain | larval stage, with Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

embryonic/larval neuron | decreased number | larval stage, with Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

ganglion mother cell | decreased number | larval stage, with Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

intermediate neuronal progenitor | decreased number | larval stage, with Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

intermediate neuronal progenitor | larval stage, with Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

mitochondrion | larval stage, with Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

type II neuroblast | decreased number | larval stage, with Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

type II neuroblast | larval stage, with Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

wing, with Scer\GAL4^bbg-C96

(Ni et al., 2008)

wing margin bristle, with Scer\GAL4^bbg-C96

(Ni et al., 2008)

Detailed Description

Statement

Reference

The expression of N^{5XUAS.JF01356} under the control of Scer\GAL4^pnt-14-94 results in decreased numbers of type II neuroblast and derived mature intermediate precursor cells, ganglion mother cells and neurons in the larval brain. Both type II neuroblasts and their daughter mature intermediate precursor cells show fragmented mitochondria.

(Dubal et al., 2022)

Expression of N^{5XUAS.JF01356} under the control of Scer\GAL4^bbg-C96 results in wing phenotypes (loss of bristles and notching) that are less severe than those seen when N^JF01356 is expressed under the same conditions. The phenotype is more severe in males than females.

(Ni et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

N^{5XUAS.JF01356}, Scer\GAL4^pnt-14-94 has decreased cell number | larval stage phenotype, suppressible | partially by Drp1^SD.UASp, Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

Phenotype Manifest In

Suppressed by

Statement

Reference

N^{5XUAS.JF01356}, Scer\GAL4^pnt-14-94 has embryonic/larval brain | larval stage phenotype, suppressible | partially by Drp1^SD.UASp, Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

N^{5XUAS.JF01356}, Scer\GAL4^pnt-14-94 has intermediate neuronal progenitor | larval stage | decreased number phenotype, suppressible | partially by Drp1^SD.UASp, Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

NOT suppressed by

Statement

Reference

N^{5XUAS.JF01356}, Scer\GAL4^pnt-14-94 has ganglion mother cell | larval stage | decreased number phenotype, non-suppressible by Drp1^SD.UASp, Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

N^{5XUAS.JF01356}, Scer\GAL4^pnt-14-94 has type II neuroblast | larval stage | decreased number phenotype, non-suppressible by Drp1^SD.UASp, Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

N^{5XUAS.JF01356}, Scer\GAL4^pnt-14-94 has embryonic/larval neuron | larval stage | decreased number phenotype, non-suppressible by Drp1^SD.UASp, Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

N^{5XUAS.JF01356}

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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