FB2024_03 , released June 25, 2024
Allele: Dmel\perSL.Tag:HA,Tag:polyHis
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General Information
Symbol
Dmel\perSL.Tag:HA,Tag:polyHis
Species
D. melanogaster
Name
FlyBase ID
FBal0280537
Feature type
allele
Associated gene
Dmel\per
Associated Insertion(s)
Carried in Construct
P{perSL.HA10His}
Key Links
Transgenic product class
missense_variant
(Ko et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Ko et al., 2007)
Mutagen
in vitro construct
(Ko et al., 2007)
Progenitor genotype
perL1
(Ko et al., 2007)
pers
(Ko et al., 2007)
perTag:HA,Tag:polyHis
(Ko et al., 2007)
Carried in construct
P{perSL.HA10His}
Cytology
Description

The mutations present in the pers and perL1 alleles (amino acid replacements S589N and V243D respectively) have been introduced into perTag:HA,Tag:polyHis.

(Ko et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
per
Encoded product / tool
per
Tagged with
Tag:HA
Tag:polyHis
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies carrying perSL.T:Ivir\HA1,T:Zzzz\His6 in a per01 background are completely arrhythmic for locomotor activity under constant darkness conditions when raised at 18, 25 or 29[o]C. Under 12 hour light: 12 hour dark conditions the flies do not show the normal evening peak of locomotor activity characteristic of rhythmic flies with 24 hour periods.

      Flies carrying perSL.T:Ivir\HA1,T:Zzzz\His6 in a wild-type background are highly arrhythmic under constant darkness conditions.

      (Ko et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      perSL.Tag:HA,Tag:polyHis fails to rescue per01

      (Ko et al., 2007)
      Comments

      perSL.T:Ivir\HA1,T:Zzzz\His6 does not the arrhythmicity seen in per01 flies under constant darkness conditions (no rescue is seen at 18, 25 and 29[o]C).

      (Ko et al., 2007)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      perSL.T:Ivir\HA1,T:Zzzz\His6
      perSL.Tag:HA,Tag:polyHis
      Name Synonyms
      Secondary FlyBase IDs
        References (2)