FB2024_03 , released June 25, 2024
Allele: Dmel\Zpr131ZZ
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General Information
Symbol
Dmel\Zpr131ZZ
Species
D. melanogaster
Name
FlyBase ID
FBal0279831
Feature type
allele
Associated gene
Dmel\Zpr1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
FLPase
(Ruiz et al., 2012)
Progenitor genotype
Cytology
Description

A nucleotide substitution results in a premature termination codon at amino acid position 58.

(Ruiz et al., 2012)

Nucleotide substitution: A172T.

(Ruiz et al., 2012)

Amino acid replacement: ?58term.

(Ruiz et al., 2012)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:9,161,803..9,161,803 [-]
Nucleotide change:

A9161803T

Reported nucleotide change:

A172T

Amino acid change:

K58term | Zpr1-PA

Reported amino acid change:

?58term

(Ruiz et al., 2012)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Zpr131ZZ mutants exhibit a complete failure to generate gas-filled lumens. Zpr131ZZ mutant cells also show a significant branching defect. Zpr131ZZ mutants are able to generate a central branch and secondary branches, but fail to undergo tertiary and quaternary branching. While the branching phenotype is highly variable, gas-filling is completely abrogated in all Zpr131ZZ mutant terminal cells.

      (Ruiz et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Overexpression of Egfr2.Scer\UAS or Egfr2.A887T.Scer\UAS in Zpr131ZZ mutant MARCM tracheal cell clones does not alter the Zpr131ZZ gas-filling defect.

      MARCM mosaics of Zpr131ZZ cells that overexpress btlScer\UAS.T:λ\cI-DD under the control of Scer\GAL4btl.PS display a Zpr131ZZ-like phenotype.

      (Ruiz et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Zpr131ZZ
      (Ruiz et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)