FB2024_03 , released June 25, 2024
Allele: Dmel\brwlMI05456
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General Information
Symbol
Dmel\brwlMI05456
Species
D. melanogaster
Name
FlyBase ID
FBal0279623
Feature type
allele
Associated gene
Dmel\brwl
Associated Insertion(s)
Mi{MIC}brwlMI05456
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    Mi{MIC}brwlMI05456
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    Mi{MIC}
    Also carries
    attP
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        brwlMI05456 is semi-lethal, as very few homozygotes eclose; heterozygotes only rarely show ovary defects.

        brwlKG00824/brwlMI05456 transheterozygotes show an array of highly prevalent and progressive ovary defects, including ovariole architecture defects, egg chambers showing decreased cell division, picnotic nuclei, loss of ring canals, mispositioned oocyte or loss a presumptive oocyte, fused egg chambers and degenerated egg chambers, as compared to controls; the germaria show progressive decreases in the number of germline cells, in synaptonemal complex formation, and in the numbers of spectrosome-positive and fusome-positive cysts, as compared to controls.

        (Shukla et al., 2018)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The progressive oogenesis defects observed in brwlKG00824/brwlMI05456 transheterozygotes (fused egg chambers, apoptotic egg chambers, absent occyte) are delayed by the expression of stwlUAS.Tag:HA,Tag:FLAG under the control of Scer\GAL4VP16.nos.UTR.

        (Shukla et al., 2018)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        CG3838MI05456
        (Bellen, 2012.11.5)
        brwlMI05456
        brwlMI0
        (Shukla et al., 2018)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)