FlyBase Allele Report: Dmel\Mtl[UAS.cMa]

General Information

Symbol

Dmel\Mtl^UAS.cMa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Munoz-Descalzo

FlyBase ID

FBal0278231

Feature type

allele

Associated gene

Dmel\Mtl

Associated Insertion(s)

Carried in Construct

P{UAS-Mtl.M}

Key Links

Transgenic product class

cDNA

(Muñoz-Descalzo et al., 2007)

wild_type

(Muñoz-Descalzo et al., 2007)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Muñoz-Descalzo et al., 2007)

wild_type

(Muñoz-Descalzo et al., 2007)

Mutagen

in vitro construct

(Muñoz-Descalzo et al., 2007)

Progenitor genotype

Carried in construct

P{UAS-Mtl.M}

Cytology

Description

UASt regulatory sequences drive expression of the complete Mtl cDNA.

(Muñoz-Descalzo et al., 2007)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Mtl

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity, with Mtl^Δ, Scer\GAL4^hs.2sev

(Muñoz-Descalzo et al., 2007)

abnormal planar polarity, with Scer\GAL4^C-765

(Muñoz-Descalzo et al., 2007)

abnormal planar polarity, with Scer\GAL4^en.PU

(Muñoz-Descalzo et al., 2007)

abnormal planar polarity, with Scer\GAL4^hs.2sev

(Muñoz-Descalzo et al., 2007)

Phenotype Manifest In

eye, with Scer\GAL4^hs.2sev

(Muñoz-Descalzo et al., 2007)

ommatidium, with Mtl^Δ, Scer\GAL4^hs.2sev

(Muñoz-Descalzo et al., 2007)

ommatidium, with Scer\GAL4^hs.2sev

(Muñoz-Descalzo et al., 2007)

wing hair, with Scer\GAL4^C-765

(Muñoz-Descalzo et al., 2007)

wing hair, with Scer\GAL4^en.PU

(Muñoz-Descalzo et al., 2007)

wing hair | increased number, with Scer\GAL4^C-765

(Muñoz-Descalzo et al., 2007)

wing hair | increased number, with Scer\GAL4^en.PU

(Muñoz-Descalzo et al., 2007)

Detailed Description

Statement

Reference

Expression of Mtl^Scer\UAS.cMa under the control of Scer\GAL4^hs.2sev results in rough eyes. 3.7% of ommatidia show defects in photoreceptor differentiation. Planar cell polarity defects are seen, with only 75.3% of ommatidia showing wild-type orientation. These defects are mostly due to misrotation of the ommatidia. In third larval instar eye discs, R3/R4 pairs are often incorrectly oriented with respect to their neighbours.

Expression of Mtl^Scer\UAS.cMa under the control of Scer\GAL4^C-765 results in planar cell polarity defects in the wing, such as a multiple wing hair phenotype and misorientation of wing hairs.

Expression of Mtl^Scer\UAS.cMa under the control of Scer\GAL4^en.PU results in planar polarity phenotypes, such as multiple wing hairs and misorientation of wing hairs, in the posterior part of the wing.

The planar polarity phenotype seen in the eyes of flies expressing Mtl^Scer\UAS.cMa under the control of Scer\GAL4^hs.2sev is enhanced in a Mtl^Δ/+ background.

(Muñoz-Descalzo et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Mtl^UAS.cMa, Scer\GAL4^hs.2sev has abnormal planar polarity phenotype, enhanceable by Cdc42[+]/Cdc42⁴

(Muñoz-Descalzo et al., 2007)

Mtl^UAS.cMa, Scer\GAL4^hs.2sev has abnormal planar polarity phenotype, enhanceable by Rac1^J11/Rac1[+]

(Muñoz-Descalzo et al., 2007)

Mtl^UAS.cMa, Scer\GAL4^hs.2sev has abnormal planar polarity phenotype, enhanceable by aos[+]/aos^rlt

(Muñoz-Descalzo et al., 2007)

Mtl^UAS.cMa, Scer\GAL4^hs.2sev has abnormal planar polarity phenotype, enhanceable by Vang^X/Vang[+]

(Muñoz-Descalzo et al., 2007)

Mtl^UAS.cMa, Scer\GAL4^hs.2sev has abnormal planar polarity phenotype, enhanceable by pk[+]/pk^pk-sple-9

(Muñoz-Descalzo et al., 2007)

NOT Enhanced by

Statement

Reference

Mtl^UAS.cMa, Scer\GAL4^hs.2sev has abnormal planar polarity phenotype, non-enhanceable by msn[+]/msn¹⁰²

(Muñoz-Descalzo et al., 2007)

Mtl^UAS.cMa, Scer\GAL4^hs.2sev has abnormal planar polarity phenotype, non-enhanceable by Rac2^Δ/Rac2[+]

(Muñoz-Descalzo et al., 2007)

Mtl^UAS.cMa, Scer\GAL4^hs.2sev has abnormal planar polarity phenotype, non-enhanceable by hep[+]/hep^r75

(Muñoz-Descalzo et al., 2007)

Mtl^UAS.cMa, Scer\GAL4^hs.2sev has abnormal planar polarity phenotype, non-enhanceable by bsk²/bsk[+]

(Muñoz-Descalzo et al., 2007)

Mtl^UAS.cMa, Scer\GAL4^hs.2sev has abnormal planar polarity phenotype, non-enhanceable by Jra^IA109/Jra[+]

(Muñoz-Descalzo et al., 2007)

Mtl^UAS.cMa, Scer\GAL4^hs.2sev has abnormal planar polarity phenotype, non-enhanceable by Rho1^72R/Rho1[+]

(Muñoz-Descalzo et al., 2007)

Suppressed by

Statement

Reference

Mtl^UAS.cMa, Scer\GAL4^hs.2sev has abnormal planar polarity phenotype, suppressible by Cdc42[+]/Cdc42³

(Muñoz-Descalzo et al., 2007)

NOT suppressed by

Statement

Reference

Mtl^UAS.cMa, Scer\GAL4^hs.2sev has abnormal planar polarity phenotype, non-suppressible by Rho1^72R/Rho1[+]

(Muñoz-Descalzo et al., 2007)

Mtl^UAS.cMa, Scer\GAL4^hs.2sev has abnormal planar polarity phenotype, non-suppressible by Rac2^Δ/Rac2[+]

(Muñoz-Descalzo et al., 2007)

Mtl^UAS.cMa, Scer\GAL4^hs.2sev has abnormal planar polarity phenotype, non-suppressible by msn[+]/msn¹⁰²

(Muñoz-Descalzo et al., 2007)

Mtl^UAS.cMa, Scer\GAL4^hs.2sev has abnormal planar polarity phenotype, non-suppressible by hep[+]/hep^r75

(Muñoz-Descalzo et al., 2007)

Mtl^UAS.cMa, Scer\GAL4^hs.2sev has abnormal planar polarity phenotype, non-suppressible by bsk²/bsk[+]

(Muñoz-Descalzo et al., 2007)

Mtl^UAS.cMa, Scer\GAL4^hs.2sev has abnormal planar polarity phenotype, non-suppressible by Jra^IA109/Jra[+]

(Muñoz-Descalzo et al., 2007)

Phenotype Manifest In

Enhanced by

Statement

Reference

Mtl^UAS.cMa, Scer\GAL4^hs.2sev has ommatidium phenotype, enhanceable by Cdc42[+]/Cdc42⁴

(Muñoz-Descalzo et al., 2007)

Mtl^UAS.cMa, Scer\GAL4^hs.2sev has ommatidium phenotype, enhanceable by Rac1^J11/Rac1[+]

(Muñoz-Descalzo et al., 2007)

Mtl^UAS.cMa, Scer\GAL4^hs.2sev has ommatidium phenotype, enhanceable by aos[+]/aos^rlt

(Muñoz-Descalzo et al., 2007)

Mtl^UAS.cMa, Scer\GAL4^hs.2sev has ommatidium phenotype, enhanceable by Vang^X/Vang[+]

(Muñoz-Descalzo et al., 2007)

Mtl^UAS.cMa, Scer\GAL4^hs.2sev has ommatidium phenotype, enhanceable by pk[+]/pk^pk-sple-9

(Muñoz-Descalzo et al., 2007)

NOT Enhanced by

Statement

Reference

Mtl^UAS.cMa, Scer\GAL4^hs.2sev has ommatidium phenotype, non-enhanceable by msn[+]/msn¹⁰²

(Muñoz-Descalzo et al., 2007)

Mtl^UAS.cMa, Scer\GAL4^hs.2sev has ommatidium phenotype, non-enhanceable by hep[+]/hep^r75

(Muñoz-Descalzo et al., 2007)

Mtl^UAS.cMa, Scer\GAL4^hs.2sev has ommatidium phenotype, non-enhanceable by Rac2^Δ/Rac2[+]

(Muñoz-Descalzo et al., 2007)

Mtl^UAS.cMa, Scer\GAL4^hs.2sev has ommatidium phenotype, non-enhanceable by bsk²/bsk[+]

(Muñoz-Descalzo et al., 2007)

Mtl^UAS.cMa, Scer\GAL4^hs.2sev has ommatidium phenotype, non-enhanceable by Jra^IA109/Jra[+]

(Muñoz-Descalzo et al., 2007)

Mtl^UAS.cMa, Scer\GAL4^hs.2sev has ommatidium phenotype, non-enhanceable by Rho1^72R/Rho1[+]

(Muñoz-Descalzo et al., 2007)

Suppressed by

Statement

Reference

Mtl^UAS.cMa, Scer\GAL4^hs.2sev has ommatidium phenotype, suppressible by Cdc42[+]/Cdc42³

(Muñoz-Descalzo et al., 2007)

NOT suppressed by

Statement

Reference

Mtl^UAS.cMa, Scer\GAL4^hs.2sev has ommatidium phenotype, non-suppressible by msn[+]/msn¹⁰²

(Muñoz-Descalzo et al., 2007)

Mtl^UAS.cMa, Scer\GAL4^hs.2sev has ommatidium phenotype, non-suppressible by hep[+]/hep^r75

(Muñoz-Descalzo et al., 2007)

Mtl^UAS.cMa, Scer\GAL4^hs.2sev has ommatidium phenotype, non-suppressible by bsk²/bsk[+]

(Muñoz-Descalzo et al., 2007)

Mtl^UAS.cMa, Scer\GAL4^hs.2sev has ommatidium phenotype, non-suppressible by Jra^IA109/Jra[+]

(Muñoz-Descalzo et al., 2007)

Mtl^UAS.cMa, Scer\GAL4^hs.2sev has ommatidium phenotype, non-suppressible by Rho1^72R/Rho1[+]

(Muñoz-Descalzo et al., 2007)

Mtl^UAS.cMa, Scer\GAL4^hs.2sev has ommatidium phenotype, non-suppressible by Rac2^Δ/Rac2[+]

(Muñoz-Descalzo et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Mtl^Scer\UAS.cMa

Mtl^UAS.cMa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Munoz-Descalzo

Secondary FlyBase IDs

References (1)

Report Sections

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