FB2024_03 , released June 25, 2024
Allele: Dmel\NKCCNIG.2509R
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General Information
Symbol
Dmel\NKCCNIG.2509R
Species
D. melanogaster
Name
FlyBase ID
FBal0273134
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Nature of the Allele
Progenitor genotype
Carried in construct
Cytology
Description

UASt regulatory sequences drive expression of a 500bp inverted repeat.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Flies expressing NKCCNIG.2509R under the control of Scer\GAL4tim.PE (but not Scer\GAL4qsm-NP6258 or Scer\GAL4qsm-NP6258) exhibit short-period locomotor rhythms in constant dim white light, in contrast to control flies which largely show arrhythmic behavior in these conditions. These flies do not exhibit any difference in locomotor rhythms when kept in constant darkness, as compared to controls.

The l-LNv neurons in flies expressing NKCCNIG.2509R under the control of Scer\GAL4Pdf.PU exhibit a hyperpolarized resting membrane potential, and a reduced spontaneous firing rate during the daytime, but not during the night, as compared to wild type; these neurons also fail to respond to blue light stimulus, in contrast to wild type.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Phenotype Manifest In
Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of NKCCNIG.2509R partially suppresses the increased spontaneous firing rate of l-LNv neurons in flies expressing qsmGD4817 under the control of Scer\GAL4tim.PE.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
CG31547NIG.2509R
NKCCNIG.2509R
Name Synonyms
Secondary FlyBase IDs
    References (3)