FB2024_03 , released June 25, 2024
Allele: Dmel\Or47b3
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General Information
Symbol
Dmel\Or47b3
Species
D. melanogaster
Name
FlyBase ID
FBal0270264
Feature type
allele
Associated gene
Dmel\Or47b
Associated Insertion(s)
TI{TI}Or47b3
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ends-out gene targeting
(Wang et al., 2011)
Progenitor genotype
Associated Insertion(s)
TI{TI}Or47b3
Cytology
Description

Genomic sequence encompassing the first two exons of Or47b plus 1kb upstream of the translation start site has been replaced by a w+* marker.

(Wang et al., 2011)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Or47b3 mutant males display a significant reduction in copulation success when courting wild-type females compared to controls and when competing for wild-type females with wild-type males.

      Compared to wild-type Or47b3 mutant males display increased copulation latency and decreased copulation success when courting oe[-] females (females, whose oenocytes had been genetically ablated by expressing hidScer\UAS.cZa under the control of Scer\GAL4Desat1.PB).

      (Dweck et al., 2015)

      The projections of Or47b-positive ORNs to the VA1lm/VA1v glomerulus is unaffected in Or47b2 homozygotes.

      Or47b2 mutant males do not show elevated male-male courtship towards oenocyte-eliminated target males, although aggression levels are unaffected.

      Or47b2 mutant males exhibit normal latencies to copulate with virgin females. The frequency of unilateral wing extensions toward females also does not show a statistically significant difference compared to controls.

      (Wang et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Or47b3 is rescued by Or47bUAS.Tag:MYC/Scer\GAL4Or47b.7.467

      (Dweck et al., 2015)
      Comments

      Expression of Or47bScer\UAS.T:Hsap\MYC under the control of Scer\GAL4Or47b.7.467 rescues the reduced copulation success of Or47b3 mutant males toward wild-type females both under competitive (with wild-type males) and non-competitive conditions (no other males present).

      (Dweck et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Or47b3
      (Dweck et al., 2015, Wang et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)