FB2024_03 , released June 25, 2024
Allele: Dmel\AckK156A.UAS
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General Information
Symbol
Dmel\AckK156A.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0270231
Feature type
allele
Associated gene
Dmel\Ack
Associated Insertion(s)
Carried in Construct
P{UAS-Ack.K156A}
Key Links
Transgenic product class
missense_variant
(Schoenherr et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Schoenherr et al., 2012)
Mutagen
in vitro construct
(Schoenherr et al., 2012)
Progenitor genotype
Carried in construct
P{UAS-Ack.K156A}
Cytology
Description

UAS regulatory sequences drive expression of a kinase inactive form of Ack.

(Schoenherr et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Ack
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing one copy of AckK156A.Scer\UAS under the control of Scer\GAL4GMR.PU have slightly larger eyes than normal, while flies expressing two copies of AckK156A.Scer\UAS under the control of Scer\GAL4GMR.PU have a highly disorganised eye.

      Expression of AckK156A.Scer\UAS under the control of Scer\GAL4GMR.PU results in an increase in the number of interommatidial bristles and a 33% decrease in the number of pigment cells when assessed at 42% pupa development.

      (Schoenherr et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      AckK156A.UAS/Scer\GAL4GMR.PU is a suppressor of visible phenotype of rprGMR.PH

      (Schoenherr et al., 2012)
      NOT Suppressor of
      Statement
      Reference

      AckK156A.UAS/Scer\GAL4GMR.PU is a non-suppressor of visible phenotype of hidAla5.GMR

      (Schoenherr et al., 2012)

      aos[+], aosΔ7, AckK156A.UAS, Scer\GAL4GMR.PU is a non-suppressor of visible phenotype of hidAla5.GMR

      (Schoenherr et al., 2012)

      RasGAP1mip-w+, Gap1[+], AckK156A.UAS, Scer\GAL4GMR.PU is a non-suppressor of visible phenotype of hidAla5.GMR

      (Schoenherr et al., 2012)

      AckK156A.UAS/Scer\GAL4GMR.PU is a non-suppressor of visible phenotype of hidGMR.PG

      (Schoenherr et al., 2012)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      AckK156A.UAS/Scer\GAL4GMR.PU is a suppressor of eye phenotype of rprGMR.PH

      (Schoenherr et al., 2012)
      NOT Suppressor of
      Statement
      Reference

      AckK156A.UAS/Scer\GAL4GMR.PU is a non-suppressor of eye phenotype of hidAla5.GMR

      (Schoenherr et al., 2012)

      aos[+], aosΔ7, AckK156A.UAS, Scer\GAL4GMR.PU is a non-suppressor of eye phenotype of hidAla5.GMR

      (Schoenherr et al., 2012)

      RasGAP1mip-w+, Gap1[+], AckK156A.UAS, Scer\GAL4GMR.PU is a non-suppressor of eye phenotype of hidAla5.GMR

      (Schoenherr et al., 2012)

      AckK156A.UAS/Scer\GAL4GMR.PU is a non-suppressor of eye phenotype of hidGMR.PG

      (Schoenherr et al., 2012)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of AckK156A.Scer\UAS under the control of Scer\GAL4GMR.PU does not modify the reduced eye size caused by WGMR.PG.

      Expression of AckK156A.Scer\UAS under the control of Scer\GAL4GMR.PU suppresses the reduced eye size caused by rprGMR.PH.

      Expression of AckK156A.Scer\UAS under the control of Scer\GAL4GMR.PU (either alone, or in conjunction with either aosΔ7/+ or Gap1mip-w+/+) does not suppress the small eye phenotype caused by WAla5.GMR.

      (Schoenherr et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      AckK156A.Scer\UAS
      AckK156A.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)