FlyBase Allele Report: Dmel\Tre1[Δ10]

General Information

Symbol

Dmel\Tre1^Δ10

Species

D. melanogaster

Name

FlyBase ID

FBal0269024

Feature type

allele

Associated gene

Dmel\Tre1

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Yoshiura et al., 2012)

Progenitor genotype

P{EP}Tre1^EP496

(Yoshiura et al., 2012)

Cytology

Description

Imprecise excision of the progenitor insertion.

(Yoshiura et al., 2012)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | embryonic stage

(Yoshiura et al., 2012)

fertile

(Yoshiura et al., 2012)

viable

(Yoshiura et al., 2012)

Phenotype Manifest In

embryonic neuroblast

(Yoshiura et al., 2012)

presumptive embryonic/larval central nervous system

(Yoshiura et al., 2012)

Detailed Description

Statement

Reference

Mutant embryos show defects in the orientation of neuroblast cell polarity, with the crescent of the Par-complex being variably oriented. The orientation of the spindle is well coordinated with the orientation of cell polarity in the mutant neuroblasts. The defects in orientation of neuroblast cell polarity result in neuroblasts, ganglion mother cells and neurons being intermingled, resulting in disorganised stratification of the developing central nervous system in the mutant embryos.

The eve-positive U neurons derived from neuroblast NB7-1 and the four eg-positive neurons derived from neuroblast NB7-3 adopt nearly normal positions in mutant embryos. The fasciculation pattern of Fas2-positive motor neurons in stage 15 mutant embryos is nearly normal.

(Yoshiura et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Tre1^Δ10 is an enhancer of abnormal neuroanatomy | embryonic stage phenotype of repo⁰³⁷⁰²

(Yoshiura et al., 2012)

Other

Statement

Reference

Tre1^Δ10, repo⁰³⁷⁰² has abnormal neuroanatomy | embryonic stage phenotype

(Yoshiura et al., 2012)

Phenotype Manifest In

Enhancer of

Statement

Reference

Tre1^Δ10 is an enhancer of larval longitudinal connective phenotype of repo⁰³⁷⁰²

(Yoshiura et al., 2012)

Other

Statement

Reference

Tre1^Δ10, repo⁰³⁷⁰² has U neuron phenotype

(Yoshiura et al., 2012)

Tre1^Δ10, repo⁰³⁷⁰² has EG neuron phenotype

(Yoshiura et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Tre1^Δ10 ; repo⁰³⁷⁰² double mutant embryos show abnormal positioning of eve-positive U neurons derived from neuroblast NB7-1 and the four eg-positive neurons derived from neuroblast NB7-3. The fasciculation of Fas2-positive motor neurons is abnormal in a high proportion of segments.

(Yoshiura et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Tre1^Δ10 is rescued by Tre1^Tag:MYC

(Yoshiura et al., 2012)

Tre1^Δ10 is rescued by Scer\GAL4^pros.PMG/Tre1^UAS.Tag:MYC

(Yoshiura et al., 2012)

Comments

Tre1^T:Hsap\MYC rescues the defect in the orientation of neuroblast cell polarity which is seen in Tre1^Δ10 embryos.

Expression of Tre1^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^pros.PMG rescues the defect in the orientation of neuroblast cell polarity which is seen in Tre1^Δ10 embryos.

(Yoshiura et al., 2012)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Tre1^Δ10

tre1^Δ10

(Yoshiura et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

Open Close