Imprecise excision of an insertion in mus205, resulting in a deletion of part of the coding region.
Mutant larvae are severely sensitive to ionising radiation, methyl methanesulfonate and nitrogen mustard.
Mutants show an approximately 50% decrease in full homologous recombination (HR) repair events in assays of excision and repair events of P{hswa}. Analysis of aborted HR products shows no significant difference in the synthesis tract lengths between repair events isolated from mutant or wild-type flies.
PolZ13B is an enhancer of abnormal DNA repair phenotype of PolD3L2
Pol32L2, DNApol-ζ3B double mutants show more pronounced DNA repair defects in a P{w[α]} assay than Pol32L2 single mutants: more severely decreased homologous recombination events than Pol32L2 and increased incomplete homologous recombination events that terminate via end joining, as compared to wild-type controls.
Pif1167, DNApol-ζ3B individuals do not show significant DNA repair defects in P{w[α]} assays: slight decrease in homologous recombination events and unchanged incomplete homologous recombination events that terminate via end joining, as compared to controls.
DNApol-η12 mus2053B double mutants show no difference in the frequency of full homologous recombination (HR) repair events in assays of excision and repair events of P{hswa} compared to wild type. The repair tract lengths in aborted HR products isolated from the double mutants are substantially increased compared to wild type.
Pol32L2 mus2053B double mutants show an approximately 70% decrease in full homologous recombination (HR) repair events in assays of excision and repair events of P{hswa} (similar to the reduction seen in Pol32L2 single mutants). Repair synthesis tract lengths are reduced dramatically in aborted HR repair products compared to wild type, and this defect is more severe than that seen in Pol32L2 single mutants.
