FB2024_03 , released June 25, 2024
Allele: Dmel\subGL00583
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General Information
Symbol
Dmel\subGL00583
Species
D. melanogaster
Name
FlyBase ID
FBal0266283
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
GL00583
Key Links
Genomic Maps

Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

UAS regulatory sequences drive expression of a short inverted repeat.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The expression of subGL00583 under the control of Scer\GAL4VP16.mat.αTub67C leads to a low frequency of meiotic spindle and centromere asymmetries in late oocytes, but does not significantly affect karyosome compaction, as compared to controls.

Expression of subGL00583 under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 in oocytes disrupts polarity of the spindle at prometaphase, with tripolar and monopolar spindles observed in a subset of oocytes, but there is no significant increase in weak/absent spindles, as compared with wild type.

Embryos derived from females expressing subGL00583 under the control of either Scer\GAL4nos.UTR.T:Hsim\VP16 or Scer\GAL4mat.αTub67C.T:Hsim\VP16 show a failure of pronuclear fusion.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Expression of subGL00583 enhances the weak/absent spindle phenotype in prometaphase oocytes expressing Spc105RGL00392 under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
subGL00583
Name Synonyms
Secondary FlyBase IDs
    References (6)