FB2024_03 , released June 25, 2024
Allele: Dmel\esgBG01042
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General Information
Symbol
Dmel\esgBG01042
Species
D. melanogaster
Name
FlyBase ID
FBal0265212
Feature type
allele
Associated gene
Dmel\esg
Associated Insertion(s)
P{GT1}esgBG01042
Carried in Construct
Key Links
Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Symonenko et al., 2018)
Mutagen
P-element activity
(Magwire et al., 2010)
Progenitor genotype
Associated Insertion(s)
P{GT1}esgBG01042
Cytology
Description

Insertion in the 3' regulatory region of esg.

(Symonenko et al., 2018)
Allele components
Component
Use(s)
Inserted element
P{GT1}
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      BG01042BG01042 mutants show a sex-antagonistic effect on lifespan, with males living longer and females living less long than controls.

      Starvation response is improved in males at 1 week but does not differ from controls at 6 weeks, whereas females show no change at 1 week but have reduced resistance at 6 weeks.

      Chill coma recovery time in males and females is similar to controls at one week, but recovery time is reduced in both sexes at 6 weeks.

      No change in climbing ability is seen in either males or females at 1 week, but improved fitness compared to controls is seen in both sexes at 6 weeks.

      (Magwire et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      BG01042BG01042 BG00297BG00297 double heterozygous males have a long lifespan compared to controls.

      BG00817BG00817 BG01042BG01042 double heterozygous females have a long lifespan compared to controls.

      (Magwire et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      BG01042BG01042
      esgBG01042
      (Symonenko et al., 2018, Magwire et al., 2010)
      esgP
      (Symonenko et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)