FB2024_03 , released June 25, 2024
Allele: Dmel\cwoPB9
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General Information
Symbol
Dmel\cwoPB9
Species
D. melanogaster
Name
FlyBase ID
FBal0261156
Feature type
allele
Associated gene
Dmel\cwo
Associated Insertion(s)
P{GSV6}GS10340
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Richier et al., 2008)
Mutagen
ethyl methanesulfonate
(Richier et al., 2008)
Progenitor genotype
P{GSV6}GS10340
(Richier et al., 2008)
Associated Insertion(s)
P{GSV6}GS10340
Cytology
Description

496 bp insertion and a 7bp deletion in exon 2 of cwo, resulting in the removal of exon 2 and frameshift in exon 3. The P{GSV6} transposon is still present.

(Richier et al., 2008)
Allele components
Component
Use(s)
Inserted element
P{GSV6}
Regulatory region(s)
UASt
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
3R:10,396,784..10,396,791 [+]
Comment:

Site of a 496 bp insertion and a 7bp deletion in exon 2 of cwo, resulting in the removal of exon 2 and frameshift in exon 3.

(Richier et al., 2008)
transposable_element_insertion_site
3R:10,388,362..10,388,362
(Richier et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous mutants display a delayed evening activity peak in LD (12 h of light, 12 h of dark) compared to controls. In DD conditions (constant darkness) cwoPB9 flies have extended (26.5 hour) rhythms for at least 10 days.

      Heterozygous flies display no difference in circadian period from controls.

      cwoPB9/Df(3R)RMSY flies have long period rhythms compared to wild type.

      (Richier et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      cwoPB9 has abnormal circadian rhythm phenotype, enhanceable by per01/per[+]

      (Richier et al., 2008)

      cwoPB9 has abnormal circadian rhythm phenotype, enhanceable by perUAS.cBa/Scer\GAL4tim.PE/per01/per[+]

      (Richier et al., 2008)

      cwoPB9 has abnormal circadian rhythm phenotype, enhanceable by perUAS.cBa/per01/Scer\GAL4cry.PE/per[+]

      (Richier et al., 2008)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Homozygous cwoPB9 flies with one copy of per01 show more severe lengthening of the circadian cycle than homozygous cwoPB9 alone.

      The length of the circadian cycle is increased when perScer\UAS.cBa is expressed in homozygous cwoPB9 flies with one copy of per01 under the control of either a Scer\GAL4tim.PE or a Scer\GAL4cry.PE driver.

      (Richier et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      PcwoB9
      (Richier et al., 2008)
      cwoPB9
      Name Synonyms
      Secondary FlyBase IDs
        References (1)