FB2024_03 , released June 25, 2024
Allele: Dmel\Cip4UAS.N.Tag:HA
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General Information
Symbol
Dmel\Cip4UAS.N.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0261000
Feature type
allele
Associated gene
Dmel\Cip4
Associated Insertion(s)
Carried in Construct
P{UAS-HA-Cip4}
Also Known As
UAS-HA-dcip4
Key Links
Transgenic product class
wild_type
(Nahm et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Nahm et al., 2010)
Mutagen
in vitro construct
(Nahm et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-HA-Cip4}
Cytology
Description

UASt regulatory sequences drive expression of Cip4 coding sequences tagged at the N-terminal with Tag:HA.

(Nahm et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Cip4
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Cip4Scer\UAS.N.T:Ivir\HA1 under the control of Scer\GAL4C57 has no effect on bouton number/muscle area or the number of satellite boutons at the third larval instar neuromuscular junction.

      (Nahm et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of both Cip4Scer\UAS.N.T:Ivir\HA1 and WASpScer\UAS.cBa under the control of Scer\GAL4C57 results in a reduction in bouton number/muscle area and in the number of satellite boutons at the third larval instar neuromuscular junction.

      (Nahm et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4da.G32/Cip4UAS.N.Tag:HA rescues Cip41

      (Nahm et al., 2010)

      Scer\GAL4C57/Cip4UAS.N.Tag:HA rescues Df(3L)ED4342/Cip41

      (Nahm et al., 2010)
      Fails to rescue

      Scer\GAL4elav-C155/Cip4UAS.N.Tag:HA fails to rescue Df(3L)ED4342/Cip41

      (Nahm et al., 2010)
      Comments

      Ubiquitous expression of Cip4Scer\UAS.N.T:Ivir\HA1 under the control of Scer\GAL4da.G32 leads to a nearly complete rescue of Cip41 lethality.

      Expression of Cip4Scer\UAS.N.T:Ivir\HA1 in Cip41/Df(3L)ED4342 trans-heterozygotes under the control of the muscle-specific Scer\GAL4C57 fully rescues the synaptic overgrowth phenotype.

      Expression of Cip4Scer\UAS.N.T:Ivir\HA1 in Cip41/Df(3L)ED4342 trans-heterozygotes under the control of the neuron-specific Scer\GAL4elav-C155 fails to rescue the synaptic overgrowth phenotype.

      (Nahm et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Cip4Scer\UAS.N.T:Ivir\HA1
      Cip4UAS.N.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (2)