FlyBase Allele Report: Dmel\Dh44-R1[KK108591]

General Information

Symbol

Dmel\Dh44-R1^KK108591

Species

D. melanogaster

Name

FlyBase ID

FBal0259702

Feature type

allele

Associated gene

Dmel\Dh44-R1

Associated Insertion(s)

Carried in Construct

P{KK108591}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK108591}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK108591

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior | adult stage

(Mohammad et al., 2016)

abnormal circadian behavior | adult stage, with Scer\GAL4^ChAT.PU

(King et al., 2017)

abnormal circadian behavior | adult stage, with Scer\GAL4^elav-C155

(King et al., 2017)

abnormal circadian behavior | adult stage, with Scer\GAL4^GMR12D05

(King et al., 2017)

abnormal circadian behavior | adult stage, with Scer\GAL4^GMR17C09

(King et al., 2017)

abnormal circadian behavior | adult stage, with Scer\GAL4^GMR21A07

(King et al., 2017)

abnormal circadian behavior | adult stage, with Scer\GAL4^GMR21G01

(King et al., 2017)

abnormal circadian behavior | adult stage, with Scer\GAL4^GMR25B12

(King et al., 2017)

abnormal circadian behavior | adult stage, with Scer\GAL4^GMR57E06

(King et al., 2017)

abnormal circadian behavior | adult stage, with Scer\GAL4^GMR87A01

(King et al., 2017)

abnormal circadian behavior | adult stage, with Scer\GAL4^nSyb.PU

(King et al., 2017)

abnormal circadian behavior | adult stage, with Scer\GAL4^S3.Hug

(King et al., 2017)

abnormal circadian behavior | adult stage, with Scer\GAL4^tim.PU

(King et al., 2017)

abnormal circadian behavior | adult stage, with Scer\GAL4^VT041379

(King et al., 2017)

abnormal circadian behavior | adult stage, with Scer\GAL4^VT055852

(King et al., 2017)

abnormal locomotor behavior | adult stage, with Scer\GAL4^nSyb.PS

(Mohammad et al., 2016)

abnormal mating behavior | mated female, with Scer\GAL4^Dh44-R1.PL

(Lee et al., 2015)

abnormal mating behavior | mated female, with Scer\GAL4^nSyb.PU

(Lee et al., 2015)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Dh44-R1^KK108591 under the control of Scer\GAL4^elav-C155, Scer\GAL4^GMR21A07, Scer\GAL4^VT055852, Scer\GAL4^VT041379, Scer\GAL4^GMR25B12, Scer\GAL4^S3.Hug, Scer\GAL4^ChAT.PU, Scer\GAL4^GMR87A01, Scer\GAL4^GMR12D05, Scer\GAL4^tim.PU, Scer\GAL4^GMR21G01, Scer\GAL4^GMR17C09, Scer\GAL4^nSyb.PU or Scer\GAL4^GMR57E06, in combination with a Dicer-2 transgene to enhance RNAi efficiency, in adults significantly reduces the strength of circadian locomotor rhythms under constant darkness, compared to controls.

(King et al., 2017)

Pan-neuronal expression of Dh44-R1^KK108591 in adult flies (using 31[o]C heat-induced Scer\GAL4^nSyb.PS in combination with Scer\GAL80^ts.αTub84B) significantly decreases wall following behavior (posited measure of anxiety) in an arena, as well as significantly decreasing walking speed, compared to non-induced (18[o]C) controls.

(Mohammad et al., 2016)

Expression of Dh44-R1^KK108591 under the control of Scer\GAL4^nSyb.PU in females results in a significant decrease in the latency to sperm ejection and a significant reduction in sperm storage in the seminal receptacles.

Expression of Dh44-R1^KK108591 under the control of Scer\GAL4^Dh44-R1.PL in females results in a significant decrease in the latency to sperm ejection and a significant reduction in sperm storage in the seminal receptacles.

(Lee et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Dh44-R1^KK108591, Scer\GAL4^elav-C155 has abnormal circadian behavior | adult stage phenotype, non-enhanceable by Dh44-R2^NIG.12370R, Scer\GAL4^elav-C155

(King et al., 2017)

NOT suppressed by

Statement

Reference

Dh44-R1^KK108591, Scer\GAL4^elav-C155 has abnormal circadian behavior | adult stage phenotype, non-suppressible by Dh44-R2^NIG.12370R, Scer\GAL4^elav-C155

(King et al., 2017)

NOT Enhancer of

Statement

Reference

Dh44-R1^KK108591, Scer\GAL4^elav-C155 is a non-enhancer of abnormal circadian behavior | adult stage phenotype of Dh44-R2^NIG.12370R, Scer\GAL4^elav-C155

(King et al., 2017)

NOT Suppressor of

Statement

Reference

Dh44-R1^KK108591, Scer\GAL4^elav-C155 is a non-suppressor of abnormal circadian behavior | adult stage phenotype of Dh44-R2^NIG.12370R, Scer\GAL4^elav-C155

(King et al., 2017)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v110708

P{KK108591}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Dh44-R1^KK108591

(Mohammad et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

Open Close