A 3650 base pair fragment from the flanking non-coding or intronic region of Dh44-R1 is fused upstream of a Drosophila core synthetic promoter (DSCP) that is followed by sequence encoding a GAL4 driver.
Thermogenetic activation (using TrpA1UAS.(B).cKa at 28[o]C) of Scer\GAL4GMR21A07 cells in adults significantly reduces the strength of circadian locomotor rhythms under constant darkness, compared to controls.