FB2024_03 , released June 25, 2024
Allele: Dmel\bin32-7
Open Close
General Information
Symbol
Dmel\bin32-7
Species
D. melanogaster
Name
FlyBase ID
FBal0258359
Feature type
allele
Associated gene
Dmel\bin3
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
FLPase
(Singh et al., 2011)
Progenitor genotype
PBac{RB}bin3e02231
(Singh et al., 2011)
P{XP}d02161
(Singh et al., 2011)
Cytology
Description

Recombination between the two progenitor insertions has deleted the genomic sequence between them, resulting in a deletion of bin3 exons 2-7 (all of the coding exons).

(Singh et al., 2011)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:6,227,930..6,241,963 [+]
Comment:

Recombination between the two progenitor insertions has deleted the genomic sequence between them, resulting in a deletion of bin3 exons 2-7 (all of the coding exons).

(Singh et al., 2011)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Only 52.5% of eggs derived from bin32-7/bin34-7 females mated to wild-type males initiate development. Approximately 18% of the undeveloped embryos show overt dorsalisation. 98.6% of eggs derived from the reciprocal cross initiate development.

      The progeny of bin34-7/bin32-7 females mated to bin3KG00599/Df(2R)Drlrv25 males show defects in egg development (only 50% of the eggs derived from the cross initiate development) and in embryogenesis (18.7% of the embryos that initiate development show embryonic lethality). The progeny of the reciprocal cross also show similar defects (65% of the eggs initiate development and 32% of the embryos that initiate development show embryonic lethality).

      Most unhatched larvae from a cross of bin32-7/bin34-7 females mated to wild-type males or from bin34-7/bin32-7 females mated to bin3KG00599/Df(2R)Drlrv25 males have defects in the formation and/or organisation of the head skeleton.

      (Singh et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      bin34-7/bin32-7 has lethal | embryonic stage | maternal effect phenotype, enhanceable by bcd6/bcd[+]

      (Singh et al., 2011)
      Suppressed by
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      bin32-7/Df(2R)ED1612 has wing phenotype, suppressible by CycTj11B2

      (Palumbo et al., 2024)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The defects seen in the progeny of bin34-7/bin32-7 females mated to bin3KG00599/Df(2R)Drlrv25 males and in the reciprocal cross are enhanced by a maternal copy of bcd6/+.

      (Singh et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      bin32-7/Df(2R)ED1612 is rescued by bin3CH322-154G8

      (Palumbo et al., 2024)
      Not rescued by

      bin32-7/Df(2R)ED1612 is not rescued by bin3UAS.Tag:HA/Scer\GAL4VP16.nanos.UTR

      (Palumbo et al., 2024)
      Comments

      One maternal copy of bin3Hsp83.PS significantly rescues the defects seen in the progeny of bin34-7/bin32-7 females mated to bin3KG00599/Df(2R)Drlrv25 males (both the defects in egg development and in embryogenesis are significantly rescued).

      The head skeleton defects of unhatched larvae from a cross of bin34-7/bin32-7 females mated to bin3KG00599/Df(2R)Drlrv25 are completely rescued in approximately 50% of cases by bin3Hsp83.PS.

      (Singh et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      bin32-7
      (Palumbo et al., 2024, Peng et al., 2023, Singh et al., 2011)
      bin3Δ
      (Palumbo et al., 2024)
      Δ2-7
      (Singh et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)