FlyBase Allele Report: Dmel\Trim9[46]

General Information

Symbol

Dmel\Trim9⁴⁶

Species

D. melanogaster

Name

FlyBase ID

FBal0258025

Feature type

allele

Associated gene

Dmel\Trim9

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Song et al., 2011)

Progenitor genotype

Trim9^NP4638

(Song et al., 2011)

Cytology

Description

Imprecise excision of P{GawB}Trim9^NP4638 (located 152bp upstream of the start codon of Trim9) generates a deletion within the 5'UTR and further upstream of Trim9.

(Song et al., 2011)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Song et al., 2011)

fertile

(Song et al., 2011)

viable

(Song et al., 2011)

Phenotype Manifest In

commissure

(Song et al., 2011)

dopaminergic neuron

(Song et al., 2011)

wing

(Song et al., 2011)

Detailed Description

Statement

Reference

Trim9⁴⁶ mutants display a droopy wing phenotype.

Trim9⁴⁶ mutants display aberrant class IV da neuron morphology. Axons frequently fail to cross the midline and some longitudinal tracts become thicker.

(Song et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Trim9⁴⁶ has abnormal neuroanatomy phenotype, enhanceable by fra³/Df(1)NP5/fra[+]/+

(Song et al., 2011)

Suppressed by

Statement

Reference

Trim9⁴⁶ has abnormal neuroanatomy phenotype, suppressible by robo[+]/Df(2R)BSC482/robo1¹/+

(Song et al., 2011)

Trim9⁴⁶ has abnormal neuroanatomy phenotype, suppressible by fra^UAS.cKa/Scer\GAL4^ppk.1.9

(Song et al., 2011)

Phenotype Manifest In

Enhanced by

Statement

Reference

Trim9⁴⁶ has dopaminergic neuron phenotype, enhanceable by fra³/Df(1)NP5/fra[+]/+

(Song et al., 2011)

Trim9⁴⁶ has commissure phenotype, enhanceable by robo[+]/fra³/robo1¹/fra[+]

(Song et al., 2011)

Suppressed by

Statement

Reference

Trim9⁴⁶ has dopaminergic neuron phenotype, suppressible by robo[+]/Df(2R)BSC482/robo1¹/+

(Song et al., 2011)

+:, Trim9⁴⁶ has commissure phenotype, suppressible by Df(2R)BSC482/Df(1)NP5/+/+

(Song et al., 2011)

Trim9⁴⁶ has dopaminergic neuron phenotype, suppressible by fra^UAS.cKa/Scer\GAL4^ppk.1.9

(Song et al., 2011)

Trim9⁴⁶ has commissure phenotype, suppressible by fra^UAS.cKa/Scer\GAL4^ppk.1.9

(Song et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

The Trim9⁴⁶ axon midline crossing phenotype is significantly enhanced in a Df(1)NP5 and fra³ heterozygous background.

Removal of one copy of robo¹ and sli (using the deficiency Df(2R)BSC482) suppresses the axon midline crossing defect found in Trim9⁴⁶ mutants.

Overexpression of fra^Scer\UAS.cKa under the control of Scer\GAL4^ppk.1.9 significantly suppresses the Trim9⁴⁶ midline crossing defects.

(Song et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Trim9⁴⁶ is rescued by Trim9^UAS.cSa/Scer\GAL4^ppk.1.9

(Song et al., 2011)

Comments

Expression of Trim9^Scer\UAS.cSa in class IV da neurons under the control of Scer\GAL4^ppk.1.9 fully rescues the guidance defects found in Trim9⁴⁶ mutants.

(Song et al., 2011)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Trim9⁴⁶

trim-9⁴⁶

(Song et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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