FlyBase Allele Report: Scer\GAL4[GMR42F06]

General Information

Symbol

Scer\GAL4^GMR42F06

Species

S. cerevisiae

Name

FlyBase ID

FBal0252448

Feature type

allele

Associated gene

Scer\GAL4

Associated Insertion(s)

Carried in Construct

P{GMR42F06-GAL4}

Also Known As

R42F06-GAL4, R42F06, GMR42F06-GAL4, T4/T5-Gal4, 42F06-GAL4

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Pfeiffer et al., 2011.2.9)

Progenitor genotype

Carried in construct

P{GMR42F06-GAL4}

Cytology

Description

A 3990 base pair fragment from the flanking non-coding or intronic region of bab2 is fused upstream of a Drosophila core synthetic promoter (DSCP) that is followed by sequence encoding a GAL4 driver.

(Pfeiffer et al., 2011.2.9)

Allele components

Component

Use(s)

Regulatory region(s)

GMR42F06

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

distribution deduced from reporter (Gal4 UAS)

Stage

Tissue/Position (including subcellular localization)

Reference

pharate adult stage

T4 neuron

(Trush et al., 2019)

T5 neuron

(Trush et al., 2019)

adult stage

T4 neuron

(Hörmann et al., 2020, Mauss et al., 2014, Maisak et al., 2013)

T5 neuron

(Hörmann et al., 2020, Mauss et al., 2014, Maisak et al., 2013)

Additional Information

Statement

Reference

ScerGAL4^GMR42F06 drives expression in T neuron T4 and T neuron T4 from 48hr APF.

(Trush et al., 2019)

Drives expression in pupal and adult T neuron T4 and T neuron T5.

(FlyBase Curators, 2017)

ScerGAL4^GMR42F06 drives expression in ChAT positive T neuron T4 and T neuron T5.

(Mauss et al., 2014)

Expression of ScerGAL4^GMR42F06 detected in the medulla (T4 cell dendrites), in the lobula (T5 cell dendrites), as well as in four distinct layers of the lobula plate, representing the terminal arborizations of both T4 and T5 cells.

(Maisak et al., 2013)

Marker for

T4 neuron

(Mauss et al., 2014)

T5 neuron

(Mauss et al., 2014)

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neurophysiology | adult stage | conditional, with Crei\ChR2^{H134R.UAS.mCherry}

(Mauss et al., 2015)

Phenotype Manifest In

vertical system neuron | conditional, with Crei\ChR2^{H134R.UAS.mCherry}

(Mauss et al., 2015)

Detailed Description

Statement

Reference

Optogenetic activation (using Crei\ChR2^{H134R.UAS.mCherry} with blue light) of Scer\GAL4^GMR42F06 cells (in a blind norpA⁷ background) in adults results in a biphasic excitatory/inhibitory response in vertical system cells, relative to baseline.

(Mauss et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

41253

w¹¹¹⁸; P{GMR42F06-GAL4}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Scer\GAL4^GMR42F06

Name Synonyms

Secondary FlyBase IDs

References (35)

Report Sections

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