FlyBase Allele Report: Dmel\Liprin-γ[H1]

General Information

Symbol

Dmel\Liprin-γ^H1

Species

D. melanogaster

Name

FlyBase ID

FBal0249005

Feature type

allele

Associated gene

Dmel\Liprin-γ

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Astigarraga et al., 2010)

Progenitor genotype

PBac{WH}Liprin-γ^f01268

(Astigarraga et al., 2010)

Caused by aberration

Df(2R)Liprin-γ^H1

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

R7 axons do not show projections extending beyond the M6 layer of the medulla in Liprin-γ^S1/Liprin-γ^H1 animals.

Liprin-γ^S1/Liprin-γ^H1 animals show no obvious defects in either the R7 projection pattern or the size of the larval neuromuscular junctions.

(Astigarraga et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Liprin-γ^H1/Liprin-γ^S1 is a suppressor | partially of abnormal neuroanatomy phenotype of Liprin-α^oos

(Astigarraga et al., 2010)

Liprin-γ^H1/Liprin-γ^S1 is a suppressor | partially of partially lethal - majority die | recessive phenotype of Liprin-α^oos

(Astigarraga et al., 2010)

Liprin-γ^H1/Liprin-γ^S1 is a suppressor of male sterile | recessive phenotype of Liprin-α^oos

(Astigarraga et al., 2010)

NOT Suppressor of

Statement

Reference

Liprin-γ^H1/Liprin-γ^S1 is a non-suppressor of abnormal neuroanatomy phenotype of Liprin-β^Δ51

(Astigarraga et al., 2010)

Liprin-γ^H1/Liprin-γ^S1 is a non-suppressor of abnormal neuroanatomy phenotype of Lar^unspecified

(Astigarraga et al., 2010)

Liprin-γ^H1/Liprin-γ^S1 is a non-suppressor of female sterile phenotype of Lar^unspecified

(Astigarraga et al., 2010)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Liprin-γ^H1/Liprin-γ^S1 is a non-enhancer of NMJ bouton | larval stage phenotype of Liprin-α^oos

(Astigarraga et al., 2010)

Suppressor of

Statement

Reference

Liprin-γ^H1/Liprin-γ^S1 is a suppressor | partially of medulla phenotype of Liprin-α^oos

(Astigarraga et al., 2010)

Liprin-γ^H1/Liprin-γ^S1 is a suppressor of NMJ bouton | larval stage phenotype of Liprin-β^Δ51

(Astigarraga et al., 2010)

Liprin-γ^H1/Liprin-γ^S1 is a suppressor | partially of NMJ bouton | larval stage phenotype of Liprin-α^oos, Liprin-β^Δ51

(Astigarraga et al., 2010)

Liprin-γ^H1/Liprin-γ^S1 is a suppressor | partially of photoreceptor cell R7 phenotype of Liprin-α^oos

(Astigarraga et al., 2010)

NOT Suppressor of

Statement

Reference

Liprin-γ^H1/Liprin-γ^S1 is a non-suppressor of NMJ bouton | larval stage phenotype of Liprin-α^oos

(Astigarraga et al., 2010)

Liprin-γ^H1/Liprin-γ^S1 is a non-suppressor of photoreceptor cell R7 phenotype of Liprin-β^Δ51

(Astigarraga et al., 2010)

Liprin-γ^H1/Liprin-γ^S1 is a non-suppressor of medulla phenotype of Liprin-β^Δ51

(Astigarraga et al., 2010)

Liprin-γ^H1/Liprin-γ^S1 is a non-suppressor of photoreceptor cell R7 phenotype of Lar^unspecified

(Astigarraga et al., 2010)

Liprin-γ^H1/Liprin-γ^S1 is a non-suppressor of medulla phenotype of Lar^unspecified

(Astigarraga et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Liprin-β^Δ51, Liprin-γ^S1/Liprin-γ^H1 double mutants form more synaptic boutons than Liprin-β^Δ51 single mutants and resemble controls.

Liprin-α^oos, Liprin-β^Δ51, Liprin-γ^S1/Liprin-γ^H1 triple mutant synapses are larger than Liprin-α^oos, Liprin-β^Δ51 double mutants.

Liprin-α^oos, Liprin-γ^S1/Liprin-γ^H1 double mutants show significantly improved R7 targeting compared with Liprin-α^oos single mutants. Double mutants also show increased viability compared to Liprin-α^oos single mutants, and double mutant males are fertile whereas Liprin-α^oos single mutant males are sterile.

(Astigarraga et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

63813

w^*; Df(2R)Liprin-γ^H1, P{neoFRT}42D Liprin-γ^H1/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Liprin-γ^H1

(Flora et al., 2018, Astigarraga et al., 2010)

liprinγ^H1

(Flora et al., 2018)

γ^H1

(Astigarraga et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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