FB2024_03 , released June 25, 2024
Allele: Dmel\mtmJF01114
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General Information
Symbol
Dmel\mtmJF01114
Species
D. melanogaster
Name
FlyBase ID
FBal0245431
Feature type
allele
Associated gene
Dmel\mtm
Associated Insertion(s)
Carried in Construct
P{TRiP.JF01114}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2008)
Mutagen
in vitro construct
(Ni et al., 2008)
Progenitor genotype
Carried in construct
P{TRiP.JF01114}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat.

(Ni et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-JF01114
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  centronuclear myopathy X-linked
      CEC
      (Collins et al., 2017)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
       

      FlyBase curator comment: 'centronuclear myopathy' subtype 'centronuclear myopathy X-linked' is associated with gene MTM1, a high-scoring human ortholog of mtm.

      (Collins et al., 2017)
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      VL3 Larval muscles expressing mtmJF01114 under the control of Scer\GAL4Mef2.PU or Scer\GAL4twi.PU exhibit nuclear positioning defects. Scer\GAL4Mef2.PU-driven expression in larval VL3 muscles induces significantly shorter internuclear distances and significantly longer distance between nuclear lines, but similar nucleus-muscle edge distance, as compared to controls; embryonic LT muscles show increased distance between dorsal end of the muscle and the nearest nucleus, but not the ventral end. Scer\GAL4twi.PU-driven expression in larval VL3 muscles induces shorter internuclear distances, but no changes in nucleus-muscle edge distance or distance between nuclear lines, as compared to controls; embryonic LT muscles show no changes in distance between dorsal or ventral end of the muscle and the nearest nucleus.

      (Collins et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Suppressor of
      NOT Suppressor of
      Phenotype Manifest In
      NOT Enhancer of
      Suppressor of
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      mtmJF01114
      Name Synonyms
      Secondary FlyBase IDs
        References (5)