FlyBase Allele Report: Dmel\dpp[JF01091]

General Information

Symbol

Dmel\dpp^JF01091

Species

D. melanogaster

Name

FlyBase ID

FBal0245409

Feature type

allele

Associated gene

Dmel\dpp

Associated Insertion(s)

Carried in Construct

P{TRiP.JF01091}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2008)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2008)

Mutagen

in vitro construct

(Ni et al., 2008)

Progenitor genotype

Carried in construct

P{TRiP.JF01091}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Ni et al., 2008)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF01091

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | adult stage, with Scer\GAL4^en-e16E

(Ni et al., 2008)

visible | male limited, with Scer\GAL4^A9

(Haley et al., 2008)

Phenotype Manifest In

wing | male limited, with Scer\GAL4^A9

(Haley et al., 2008)

wing vein, with Scer\GAL4^en-e16E

(Ni et al., 2008)

Detailed Description

Statement

Reference

The adulthood-only expression of dpp^JF01091 under the control of Scer\GAL4^C587 and Gal80[ts] does not affect the tissue homeostasis of adult testes, as compared to controls.

(Zhang et al., 2017)

Expression of dpp^JF01091 under the control of Scer\GAL4^A9 produces weak wing phenotypes in males. Females completely lack a phenotype.

(Haley et al., 2008)

Expression of dpp^JF01091 under the control of Scer\GAL4^en-e16E results in loss of wing veins. The phenotype is more severe in males than females.

(Ni et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

dpp^JF01091, Scer\GAL4^C587 is a suppressor | partially of increased cell number | female | adult stage phenotype of Psc^GD4481, Scer\GAL4^C587, Su(z)2^GD16388

(Li et al., 2016)

dpp^JF01091, Scer\GAL4^C587 is a suppressor | partially of neoplasia | female | adult stage phenotype of Psc^GD4481, Scer\GAL4^C587, Su(z)2^GD16388

(Li et al., 2016)

Scer\GAL4^C587/dpp^JF01091 is a suppressor of increased cell number | oogenesis phenotype of Scer\GAL4^C587, en^UAS.EGFP

(Eliazer et al., 2014)

NOT Suppressor of

Statement

Reference

dpp^JF01091, Scer\GAL4^C587 is a non-suppressor of increased cell number | spermatogenesis phenotype of Pc^NIG.32443R, Scer\GAL4^C587

(Zhang et al., 2017)

Phenotype Manifest In

Suppressor of

Statement

Reference

dpp^JF01091, Scer\GAL4^C587 is a suppressor | partially of germarium phenotype of Psc^GD4481, Scer\GAL4^C587, Su(z)2^GD16388

(Li et al., 2016)

dpp^JF01091, Scer\GAL4^ptc.PU is a suppressor | partially of germarium phenotype of Cul2^GD8913, Scer\GAL4^ptc.PU

(Ayyub et al., 2015)

dpp^JF01091, Scer\GAL4^ptc.PU is a suppressor | partially of spectrosome phenotype of Cul2^GD8913, Scer\GAL4^ptc.PU

(Ayyub et al., 2015)

Scer\GAL4^C587/dpp^JF01091 is a suppressor of female germline stem cell | increased number | oogenesis phenotype of Scer\GAL4^C587, en^UAS.EGFP

(Eliazer et al., 2014)

Scer\GAL4^C587/dpp^JF01091 is a suppressor of female germline stem cell | increased number phenotype of Scer\GAL4^C587, Su(var)3-3^NIG.17149R

(Eliazer et al., 2011)

NOT Suppressor of

Statement

Reference

dpp^JF01091, Scer\GAL4^C587 is a non-suppressor of cyst progenitor cell | spermatogenesis phenotype of Pc^NIG.32443R, Scer\GAL4^C587

(Zhang et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The co-expression of dpp^JF01091 does not suppress the increased number of cyst stem cells in adult testes resulting from the adulthood-only expression of Pc^NIG.32443R under the control of Scer\GAL4^C587 and Gal80[ts].

(Zhang et al., 2017)

Simultaneous expression of both Psc^GD4481 and Su(z)2^GD16388 under the control of Scer\GAL4^C587 (together with tub-Gal80[ts] to limit the time of expression to adulthood) results in tumorigenic accumulation of spectrosome containing germline stem cell-like (GSC-like) cells (which increase in number with the time of expression) in female germaria; this accumulation of GSC-like cells is significantly suppressed by co-expression of dpp^JF01091.

(Li et al., 2016)

The increased number of spectrosome-containing cells in germaria characteristic for adult females expressing Cul2^GD8913 RNAi under the control of the Scer\GAL4^ptc.PU can be partially rescued by combination with either dpp^hr92, dpp^hr56 or tkv⁷ in a heterozygous state or by knocking-down dpp by co-expression of either dpp^JF01090 or dpp^JF01091 RNAi.

(Ayyub et al., 2015)

Co-expression of dpp^JF01091 with Su(var)3-3^NIG.17149R under the control of Scer\GAL4^C587 strongly suppresses the supernumerary germline stem cell phenotype resulting from the expression of Su(var)3-3^NIG.17149R.

(Eliazer et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

31531

y¹ v¹; P{TRiP.JF01091}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

dpp^JF01091

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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