FB2024_03 , released June 25, 2024
Allele: Dmel\Rbfox1UAS.cUa
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General Information
Symbol
Dmel\Rbfox1UAS.cUa
Species
D. melanogaster
Name
FlyBase ID
FBal0244816
Feature type
allele
Associated gene
Dmel\Rbfox1
Associated Insertion(s)
Carried in Construct
P{UAS-Rbfox1.U}
Also Known As
UAS-Rbfox1
Key Links
Transgenic product class
cDNA
(Usha and Shashidhara, 2010)
wild_type
(Usha and Shashidhara, 2010)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Usha and Shashidhara, 2010)
wild_type
(Usha and Shashidhara, 2010)
Mutagen
in vitro construct
(Usha and Shashidhara, 2010)
Progenitor genotype
Carried in construct
P{UAS-Rbfox1.U}
Cytology
Description

UAS regulatory sequences drive expression of the LD15974 cDNA representing the full-length Rbfox1-RE isoform.

(Usha and Shashidhara, 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Rbfox1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  syndromic intellectual disability
      modeled by U2af50JF02693
      (Li et al., 2024)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of Rbfox1Scer\UAS.cUa under the control of Scer\GAL4sca-109-68 leads to near lethality, and the few escapers exhibit complete loss of thoracic sensory macrochaeta and a severe loss of thoracic sensory microchaeta, leading to a 'bald appearance', which are associated with a significant decrease in the number of sensory organ precursor cells in third instar larval wing discs, as compared to controls.

      (Shukla et al., 2017)

      Conditional expression of Rbfox1Scer\UAS.RN, using Scer\GAL80ts.αTub84B to limit expression to adult stage, under the control of Scer\GAL4GMR13F02 results in enhanced 3 hr memory in an aversive olfactory memory assay in adults compared to controls without altering odor or shock avoidance.

      (Guven-Ozkan et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      NOT Enhancer of
      Suppressor of
      NOT Suppressor of
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The co-expression of both Rbfox1Scer\UAS.cUa and NDN.Scer\UAS under the control of Scer\GAL4sca-C253 results in the virtual loss of thoracic sensory macrochaeta, but not microchaeta, as compared to controls.

      The severe loss of thoracic sensory macrochaeta and microchaeta observed upon the expression of Rbfox1Scer\UAS.cUa alone under the control of Scer\GAL4sca-109-68 is partially suppressed by the co-expression of sensScer\UAS.cNa.

      (Shukla et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      A2bp1Scer\UAS.cUa
      Rbfox1Scer\UAS.cUa
      Rbfox1UAS.cUa
      Name Synonyms
      Secondary FlyBase IDs
        References (6)