FlyBase Allele Report: Dmel\kibra[UASp.cYa]

General Information

Symbol

Dmel\kibra^UASp.cYa

Species

D. melanogaster

Name

FlyBase ID

FBal0244408

Feature type

allele

Associated gene

Dmel\kibra

Associated Insertion(s)

Carried in Construct

P{UASp-kibra.Y}

Key Links

Transgenic product class

cDNA

(Yu et al., 2010)

wild_type

(Yu et al., 2010)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Yu et al., 2010)

wild_type

(Yu et al., 2010)

Mutagen

in vitro construct

(Yu et al., 2010)

Progenitor genotype

Carried in construct

P{UASp-kibra.Y}

Cytology

Description

UASp regulatory sequences drive expression of the kibra RE26350 cDNA clone.

(Yu et al., 2010)

Allele components

Component

Use(s)

Regulatory region(s)

UASp

binary expression system - regulatory region

Encoded product / tool

kibra

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage, with Scer\GAL4^nub-AC-62

(Su et al., 2017)

increased cell death, with Scer\GAL4^GMR.PF

(Yu et al., 2010)

visible, with Scer\GAL4^GMR.PF

(Yu et al., 2010, Yu et al., 2010)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PF

(Yu et al., 2010, Yu et al., 2010)

eye disc, with Scer\GAL4^GMR.PF

(Yu et al., 2010)

wing blade, with Scer\GAL4^nub-AC-62

(Su et al., 2017)

Detailed Description

Statement

Reference

Expression of kibra^{Scer\UAS.P\T.cYa} under the control of Scer\GAL4^nub-AC-62 leads to reduced size of adult wing blade.

(Su et al., 2017)

Expression of kibra^{Scer\UAS.P\T.cYa} under the control of Scer\GAL4^GMR.PF results in a reduction in the size of the adult eye.

(Yu et al., 2010)

Expression of kibra^{Scer\UAS.P\T.cYa} under the control of Scer\GAL4^GMR.PF results in ectopic apoptosis in the eye imaginal disc and adults with smaller eyes than normal.

(Yu et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^nub-AC-62, kibra^UASp.cYa has abnormal size | adult stage phenotype, enhanceable by Scer\GAL4^nub-AC-62/crb^GD14463

(Su et al., 2017)

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PF, kibra^UASp.cYa has visible phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^GMR.PF

(Yu et al., 2010)

Scer\GAL4^GMR.PF, kibra^UASp.cYa has increased cell death phenotype, suppressible | somatic clone by sav^shrp-1/sav^shrp-1

(Yu et al., 2010)

Suppressor of

Statement

Reference

Scer\GAL4^nub-AC-62/kibra^UASp.cYa is a suppressor of abnormal size | adult stage phenotype of Scer\GAL4^nub-AC-62, ex^KK100573

(Su et al., 2017)

Scer\GAL4^nub-AC-62/kibra^UASp.cYa is a suppressor of abnormal size | adult stage phenotype of Scer\GAL4^nub-AC-62, crb^GD14463

(Su et al., 2017)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^nub-AC-62, kibra^UASp.cYa has wing blade phenotype, enhanceable by Scer\GAL4^nub-AC-62/crb^GD14463

(Su et al., 2017)

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PF, kibra^UASp.cYa has eye phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^GMR.PF

(Yu et al., 2010)

Suppressor of

Statement

Reference

Scer\GAL4^nub-AC-62/kibra^UASp.cYa is a suppressor of wing blade phenotype of Scer\GAL4^nub-AC-62, ex^KK100573

(Su et al., 2017)

Scer\GAL4^nub-AC-62/kibra^UASp.cYa is a suppressor of wing blade phenotype of Scer\GAL4^nub-AC-62, crb^GD14463

(Su et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The increased size of adult wing blade characteristic for flies expressing ex^KK100573 under the control of Scer\GAL4^nub-AC-62 is suppressed by co-expression of kibra^{Scer\UAS.P\T.cYa}, which on its own leads to reduced adult wing size.

The wing undergrowth observed in flies expressing kibra^{Scer\UAS.P\T.cYa} under the control of Scer\GAL4^nub-AC-62 (their wing area is significantly decreased compared to controls) is further reduced by co-expression of crb^GD14463 (which on its own leads to wing overgrowth).

(Su et al., 2017)

Co-expression of kibra^{Scer\UAS.P\T.cYa} and yki^Scer\UAS.cHa under the control of Scer\GAL4^GMR.PF results in an eye size similar to that caused by expression of yki^Scer\UAS.cHa alone under the control of Scer\GAL4^GMR.PF.

Homozygous sav^shrp-1 eyes (induced by the eyFLP method) that are also expressing kibra^{Scer\UAS.P\T.cYa} under the control of Scer\GAL4^GMR.PF show overgrowth similar to that seen in eyes that are mutant for sav^shrp-1 alone. In the eye discs of these animals, the ectopic cell death that is induced by expression of kibra^{Scer\UAS.P\T.cYa} under the control of Scer\GAL4^GMR.PF in a wild-type background is suppressed in the sav^shrp-1 clones.

(Yu et al., 2010)

Xenogenetic Interactions

Statement

Reference

The reduction in eye size caused by expression of kibra^{Scer\UAS.P\T.cYa} under the control of Scer\GAL4^GMR.PF is significantly suppressed by co-expression of BacA\p35^Scer\UAS.cHa.

(Yu et al., 2010)

Complementation and Rescue Data

Rescues

Scer\GAL4^Act.PU/kibra^UASp.cYa rescues kibra^del

(Yu et al., 2010)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

kibra^{Scer\UAS.P\T.cYa}

kibra^UASp.cYa

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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