FB2024_03 , released June 25, 2024
Allele: Dmel\l(2)gd1UAS.cJa
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General Information
Symbol
Dmel\l(2)gd1UAS.cJa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Jaekel
FlyBase ID
FBal0244207
Feature type
allele
Associated gene
Dmel\l(2)gd1
Associated Insertion(s)
Carried in Construct
P{UAS-l(2)gd1.J}
Key Links
Transgenic product class
cDNA
(Jaekel and Klein, 2006)
wild_type
(Jaekel and Klein, 2006)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Jaekel and Klein, 2006)
wild_type
(Jaekel and Klein, 2006)
Mutagen
in vitro construct
(Jaekel and Klein, 2006)
Progenitor genotype
Carried in construct
P{UAS-l(2)gd1.J}
Cytology
Description

UAS drives expression of the full-length LD23056 l(2)gd1 cDNA.

(Jaekel and Klein, 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
l(2)gd1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of l(2)gd1Scer\UAS.cJa under the control of Scer\GAL4C5 results in partial thickening and short interruptions of wing veins.

      (Troost et al., 2012)

      Expression of a weak l(2)gd1Scer\UAS.cJa insertion line using Scer\GAL4sd-SG29.1 results in a broadening of wing veins, loss of wing margin in proximal regions, and sometimes formation of extra bristles. Expression of a strong line, or co-expression of two lines, results in expansion of the distal wing margin but loss of the proximal margin.

      Expression of l(2)gd1Scer\UAS.cJa using Scer\GAL4ptc-559.1 results in loss of the anterior cross-vein and loss of scutellar bristles. Sensory organ precursors in the wing disc do not form.

      Expression of l(2)gd1Scer\UAS.cJa using Scer\GAL4ptc-559.1 results in the formation/accumulation of late endosomes in the wing disc cells.

      (Jaekel and Klein, 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The wing phenotype caused by expression of l(2)gd1Scer\UAS.cJa under the control of Scer\GAL4C5 is strongly modified if the flies are also heterozygous for either Df(2R)Np5, Df(2R)w45-30n or shrb4.

      (Troost et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4da.G32/l(2)gd1UAS.cJa rescues l(2)gd1d7

      (Jaekel and Klein, 2006)
      Comments

      Expression of l(2)gd1Scer\UAS.cJa using Scer\GAL4da.G32 rescues the aberrant morphology and size of l(2)gd1d7 wing discs.

      (Jaekel and Klein, 2006)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      l(2)gd1Scer\UAS.cJa
      l(2)gd1UAS.cJa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Jaekel
      Secondary FlyBase IDs
        References (2)