FB2024_03 , released June 25, 2024
Allele: Dmel\Cbl1
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General Information
Symbol
Dmel\Cbl1
Species
D. melanogaster
Name
FlyBase ID
FBal0243525
Feature type
allele
Associated gene
Dmel\Cbl
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Robertson et al., 2000)
Progenitor genotype
Caused by aberration
Df(3L)Cbl1
Cytology
Description

The 5' breakpoint of Df(3L)Cbl1 is at the site of the PBac{5HPw+}A395 insertion. The 3' breakpoint is as yet undefined but is at least 10kb 3' of the Cbl gene.

(Robertson et al., 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The wild-type segmental array of neurons is disrupted in Cbl1 mutants and some embryos fail to form the appropriate number of neurons in each segment. The phenotype is pleiotropic, possibly due to varying degrees of maternal rescue.

      Cbl1 animals have cephalopharyngeal defects and variable cuticle defects. In animals with well formed cuticle, segment deletions and fusions are common. Small perforations that may reflect a dorsal closure defect are also observed.

      Heterozygous Cbl1 flies are phenotypically wild-type.

      Flies heterozygous for both Cbl1 and Scer\GAL4GMR.PF;CblDv.Scer\UAS exhibit a significantly enhanced Scer\GAL4GMR.PF;CblDv.Scer\UAS phenotype, with pronounced disruption of the ommatidial array and an increase in the number of ommatidia with ectopic photoreceptors.

      (Robertson et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      Flies heterozygous for both Cbl1 and Scer\GAL4GMR.PF;CblDv.Scer\UAS exhibit a significantly enhanced Scer\GAL4GMR.PF;CblDv.Scer\UAS phenotype, with pronounced disruption of the ommatidial array and an increase in the number of ommatidia with ectopic photoreceptors.

      (Robertson et al., 2000)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Cbl1
      (Robertson et al., 2000)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)