FlyBase Allele Report: Dmel\Pdp1[3135]

General Information

Symbol

Dmel\Pdp1³¹³⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0243453

Feature type

allele

Associated gene

Dmel\Pdp1

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Zheng et al., 2009)

Progenitor genotype

Cytology

Description

A 4 bp deletion in the second exon of the Pdp1-RD and Pdp1-RJ isoforms of Pdp1. The deletion results in a frame shift starting from residue 262 and a predicted truncated polypeptide of 374 amino acids. The Pdp1³¹³⁵ mutation is predicted to abolish the ε isoform of Pdp1, but leave the other isoforms intact.

(Zheng et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:7,830,791..7,830,794 [-]

Comment:

A 4 bp deletion that causes a frameshift after amino acid residue 261 of isoforms Pdp1-RD and Pdp1-RJ.

(Zheng et al., 2009)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal circadian behavior (with Pdp1^d11071)

(Zheng et al., 2009)

abnormal circadian behavior | recessive

(Zheng et al., 2009)

viable

(Zheng et al., 2009)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygous Pdp1³¹³⁵ mutant flies exhibit abnormal circadian locomotor activities. While control flies are rhythmic, Pdp1³¹³⁵ mutant flies, as homozygotes and transheterozygotes over the null allele Pdp1^P205, are arrhythmic under light:dark and constant darkness conditions.

(Zheng et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions