FB2024_03 , released June 25, 2024
Allele: Dmel\Syx18ex6
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General Information
Symbol
Dmel\Syx18ex6
Species
D. melanogaster
Name
FlyBase ID
FBal0241369
Feature type
allele
Associated gene
Dmel\Syx18
Associated Insertion(s)
P{?EPgy2}Syx18ex6
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Gorczyca et al., 2007)
Mutagen
Delta2-3 transposase
(Gorczyca et al., 2007)
Progenitor genotype
P{EPgy2}Syx18EY08095
(Gorczyca et al., 2007)
Associated Insertion(s)
P{?EPgy2}Syx18ex6
Cytology
Description

Partial excision of the progenitor insertion, such that approximately 500 bp of the original insertion remain within the first exon, and flanking sequences are intact.

(Gorczyca et al., 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutants survive to the second instar larval stage with a few third instar escapers.

      Muscles 6 and 7 are significantly smaller in Syx18ex6 third instar larvae than in controls.

      Mutant larvae show an altered configuration of the muscle endomembrane system compared to controls, which is suggestive of a collapse of the cortical network into the subcortical network.

      Syx18ex6 third instar larvae have enlarged and bulbous boutons at the neuromuscular junction (NMJ), often with only one or two boutons per NMJ branch. The overall number of boutons per muscle area is reduced compared to controls (the NMJs of muscles 6 and 7 have been analysed). There is an increase in bouton cross-sectional area and a decrease in the length of the subsynaptic reticulum (SSR) in the mutant NMJ compared to controls.

      Mutant larvae show small but significant decreases in the amplitude and decay time constant of evoked excitatory junctional potentials (EJP). The mutants show a decreased frequency of spontaneous mini excitatory junction potentials (mEJP), although the mEJP amplitude is normal. The excitatory junctional current (EJC) amplitude is decreased compared to controls, but the EJC decay constant is normal.

      (Gorczyca et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      Syx18ex6 is partially rescued by Syx18UAS.cGa/Scer\GAL4T80

      (Gorczyca et al., 2007)

      Syx18ex6 is partially rescued by Syx18UAS.cGa/Scer\GAL4C57

      (Gorczyca et al., 2007)
      Not rescued by

      Syx18ex6 is not rescued by Scer\GAL4futsch-C380/Syx18UAS.cGa

      (Gorczyca et al., 2007)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Syx18ex6
      gtxex6
      (Gorczyca et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)