FB2024_03 , released June 25, 2024
Allele: Dmel\ZnT63CUAS.cWa
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General Information
Symbol
Dmel\ZnT63CUAS.cWa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Wang
FlyBase ID
FBal0241247
Feature type
allele
Associated gene
Dmel\ZnT63C
Associated Insertion(s)
Carried in Construct
P{UAS-ZnT63C.W}
Also Known As
UAS-dZnT1
Key Links
Transgenic product class
cDNA
(Wang et al., 2009)
wild_type
(Wang et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Wang et al., 2009)
wild_type
(Wang et al., 2009)
Mutagen
in vitro construct
(Wang et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-ZnT63C.W}
Cytology
Description

UASt regulatory sequences drive expression of a ZnT63C cDNA.

(Wang et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
ZnT63C
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      No obvious eye phenotypes are seen when ZnT63CScer\UAS.cWa is expressed under the control of Scer\GAL4elav.PU.

      (Huang et al., 2014)

      Expression of ZnT63CScer\UAS.cWa-driven by Scer\GAL4da.G32 results in decreased eclosion rates under excessive dietary zinc conditions compared to controls. The lethality mainly happens before pupation.

      Scer\GAL4da.G32-driven ZnT63CScer\UAS.cWa expression does not increase the sensitivity of the larvae to dietary copper as measured by survival rates.

      (Wang et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      ZnT63CUAS.cWa, Scer\GAL4elav.PU is an enhancer of eye phenotype of Hsap\MAPTR406W.UAS, Scer\GAL4elav.PU

      (Huang et al., 2014)
      Suppressor of
      Statement
      Reference

      ZnT63CUAS.cWa, Scer\GAL4elav.PU is a suppressor of eye phenotype of Hsap\MAPTR406W.UAS, Scer\GAL4elav.PU

      (Huang et al., 2014)
      NOT Suppressor of
      Statement
      Reference

      Scer\GAL4Mef2.PU/ZnT63CUAS.cWa is a non-suppressor of fusion competent cell phenotype of foiC887

      (Carrasco-Rando et al., 2016)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of ZnT63CScer\UAS.cWa under the control of Scer\GAL4Mef2.PU fails to rescue the faulty specification of fusion-competent myoblasts in foiC887/foiC887 mutants.

      (Carrasco-Rando et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference

      Expression of ZnT63CScer\UAS.cWa partially suppresses the rough eye phenotype seen in flies expressing Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav.PU. Lifespan is also increased. The number of brain vacuoles in reduced.

      (Huang et al., 2014)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      ZnT63CScer\UAS.cWa
      ZnT63CUAS.cWa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Wang
      Secondary FlyBase IDs
        References (6)