FlyBase Allele Report: Dmel\γCOP[10]

General Information

Symbol

Dmel\γCOP¹⁰

Species

D. melanogaster

Name

FlyBase ID

FBal0240989

Feature type

allele

Associated gene

Dmel\γCOP

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Grieder et al., 2008)

Progenitor genotype

P{lArB}γCOP^A383.2M3

(Grieder et al., 2008)

Cytology

Description

Imprecise excision of the progenitor insertion, resulting in a deletion that removes part of the γCop gene.

(Grieder et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:31,571,151..31,573,051 [+]

(Grieder et al., 2008)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage | progressive | somatic clone

(Maddison et al., 2023)

lethal - all die during embryonic stage | recessive

(Grieder et al., 2008)

some die during embryonic stage | recessive

(Grieder et al., 2008)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygotes die as late embryos with almost transparent cuticles and only weakly visible denticles.

Homozygous embryos show a number of tracheal defects. The branching pattern is often similar or identical to that of wild-type embryos, but the dorsal branches are often disrupted and form cyst-like structures rather than extended branches linked up to the dorsal trunk. The lumen of the dorsal trunk is much narrower in the mutant embryos than in wild type. and the dorsal trunk shows defects in lumen fusion, seen as interruptions in the luminal chitin cable at the dorsal trunk. Defects in lateral trunk fusion are also seen.

(Grieder et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

γCOP¹⁰ has embryonic/larval dorsal tracheal branch phenotype, suppressible by Scer\GAL4^btl.PS/pio^UAS.cJa

(Grieder et al., 2008)

NOT suppressed by

Statement

Reference

γCOP¹⁰ has embryonic/larval tracheal dorsal trunk phenotype, non-suppressible by Scer\GAL4^btl.PS/pio^UAS.cJa

(Grieder et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of pio^Scer\UAS.cJa under the control of Scer\GAL4^btl.PS rescues the dorsal branch defects seen in γCop¹⁰ homozygous embryos. However, the dorsal trunk defects which are seen in γCop¹⁰ homozygous embryos are not rescued by expression of pio^Scer\UAS.cJa under the control of Scer\GAL4^btl.PS.

(Grieder et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

γCOP¹⁰ is rescued by γCOP^Ω35

(Grieder et al., 2008)

γCOP¹⁰ is rescued by γCOP^Ω38.mRFP1

(Grieder et al., 2008)

γCOP¹⁰ is rescued by γCOP^UASp.cGa/Scer\GAL4^btl.PS

(Grieder et al., 2008)