FB2024_03 , released June 25, 2024
Allele: Dmel\mRpL34248
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General Information
Symbol
Dmel\mRpL34248
Species
D. melanogaster
Name
FlyBase ID
FBal0239925
Feature type
allele
Associated gene
Dmel\mRpL34
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Caused by aberration
    Df(2R)Dg248
    Cytology
    Description

    Deletion of genomic sequences, which affects the first exon of Dg and also affects mRpL34 (removing up to the start codon).

    (Mirouse et al., 2009)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Other
        Statement
        Reference

        Dg248, mRpL34248 has follicle cell | somatic clone phenotype

        (Mirouse et al., 2009)
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer

        One copy of P{mRpL34+t1.3} completely rescues the lethality and sterility of Df(2R)Dg323/Df(2R)Dg248 transheterozygotes. Thus the lethality of the Df(2R)Dg248 chromosome is not due to an effect on Dg, but is due to disruption of mRpL34.

        (Mirouse et al., 2009)

        One copy of P{mRpL34+t1.3} completely rescues the polarity defects of Df(2R)Dg248 homozygous follicle cell clones. Expression of DgScer\UAS.cDb under the control of Scer\GAL4da.G32 also rescues the polarity defects of Df(2R)Dg248 homozygous follicle cell clones. Thus the apical-basal polarity defect of the Df(2R)Dg248 chromosome is due to concomitant disruption of both mRpL34 and Dg.

        (Mirouse et al., 2009)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        mRpL34248
        Name Synonyms
        Secondary FlyBase IDs
          References (2)