FB2024_03 , released June 25, 2024
Allele: Dmel\pnrVX1e
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General Information
Symbol
Dmel\pnrVX1e
Species
D. melanogaster
Name
FlyBase ID
FBal0239729
Feature type
allele
Associated gene
Dmel\pnr
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Heterozygous adults show an increase in heart arrest/fibrillation compared to control flies upon electrical pacing of the heart. The severity of the defect increases with age.

        (Qian and Bodmer, 2009)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        NOT Enhanced by
        Statement
        Reference

        pnrVX1e has adult heart phenotype, non-enhanceable by tin346/tin[+]

        (Qian and Bodmer, 2009)

        pnrVX1e has adult heart phenotype, non-enhanceable by Df(3R)GC14/+

        (Qian and Bodmer, 2009)

        pnrVX1e has adult heart phenotype, non-enhanceable by H15nmr-614/H15[+]

        (Qian and Bodmer, 2009)

        pnrVX1e has adult heart phenotype, non-enhanceable by Df(2L)Exel6012/+

        (Qian and Bodmer, 2009)
        NOT suppressed by
        Statement
        Reference

        pnrVX1e has adult heart phenotype, non-suppressible by tin346/tin[+]

        (Qian and Bodmer, 2009)

        pnrVX1e has adult heart phenotype, non-suppressible by Df(3R)GC14/+

        (Qian and Bodmer, 2009)

        pnrVX1e has adult heart phenotype, non-suppressible by H15nmr-614/H15[+]

        (Qian and Bodmer, 2009)

        pnrVX1e has adult heart phenotype, non-suppressible by Df(2L)Exel6012/+

        (Qian and Bodmer, 2009)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The increase in heart arrest/fibrillation upon electrical pacing that is seen in pnrVX1e/+ adults is not significantly altered by tin346/+ or Df(3R)GC14/+.

        The increase in heart arrest/fibrillation upon electrical pacing that is seen in pnrVX1e/+ adults is not significantly altered by H15nmr-614/+ or Df(2L)Exel6012/+.

        (Qian and Bodmer, 2009)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        pnrVX1e
        (Qian and Bodmer, 2009)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)