FlyBase Allele Report: Dmel\eya[JF03160]

General Information

Symbol

Dmel\eya^JF03160

Species

D. melanogaster

Name

FlyBase ID

FBal0239659

Feature type

allele

Associated gene

Dmel\eya

Associated Insertion(s)

Carried in Construct

P{TRiP.JF03160}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.JF03160}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF03160

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | adult stage, with Scer\GAL4^ato.3'348

(Yu et al., 2015)

visible | adult stage, with Scer\GAL4^ey.PU

(Yu et al., 2015)

visible | adult stage, with Scer\GAL4^GMR.PU

(Yu et al., 2015)

Phenotype Manifest In

eye | adult stage, with Scer\GAL4^ato.3'348

(Yu et al., 2015)

eye | adult stage, with Scer\GAL4^ey.PU

(Yu et al., 2015)

eye | adult stage, with Scer\GAL4^GMR.PU

(Yu et al., 2015)

eye disc | third instar larval stage, with Scer\GAL4^ato.3'348

(Yu et al., 2015)

eye disc | third instar larval stage, with Scer\GAL4^ey.PU

(Yu et al., 2015)

photoreceptor neuron | third instar larval stage, with Scer\GAL4^ato.3'348

(Yu et al., 2015)

photoreceptor neuron | third instar larval stage, with Scer\GAL4^ey.PU

(Yu et al., 2015)

Detailed Description

Statement

Reference

Expression of eya^JF03160 (together with UAS-Dicer2 to enhance RNAi efficiency) under the control of Scer\GAL4^ey.PU leads to absence of photoreceptor neurons in third instar larval eye disc and consequently a complete loss of adult eye. Expression under Scer\GAL4^GMR.PU results in rough eye adult phenotype but the photoreceptor neurons are recruited normally during eye morphogenesis and expression under Scer\GAL4^ato.3'348 leads to a partial loss of photoreceptor neurons in the developing eye disc and small and rough adult eyes.

(Yu et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Scer\GAL4^elav.PU/eya^JF03160 is a non-enhancer of increased size | larval stage phenotype of Scer\GAL4^elav.PU, kon^{UAS.Tag:HA,Tag:SS(wg)}

(Harrison et al., 2021)

Suppressor of

Statement

Reference

Scer\GAL4^repo.PU/eya^JF03160 is a suppressor of increased size | larval stage phenotype of Scer\GAL4^repo.PU, kon^{UAS.Tag:HA,Tag:SS(wg)}

(Harrison et al., 2021)

NOT Suppressor of

Statement

Reference

Scer\GAL4^elav.PU/eya^JF03160 is a non-suppressor of increased size | larval stage phenotype of Scer\GAL4^elav.PU, kon^{UAS.Tag:HA,Tag:SS(wg)}

(Harrison et al., 2021)

Other

Statement

Reference

Scer\GAL4^esg-MH766, Scer\GAL80^ey.3.5, eya^JF03160, so^KK108128 has abnormal neuroanatomy | third instar larval stage phenotype

(Apitz and Salecker, 2016)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Scer\GAL4^elav.PU/eya^JF03160 is a non-enhancer of larval ventral nerve cord phenotype of Scer\GAL4^elav.PU, kon^{UAS.Tag:HA,Tag:SS(wg)}

(Harrison et al., 2021)

Suppressor of

Statement

Reference

Scer\GAL4^repo.PU/eya^JF03160 is a suppressor of larval ventral nerve cord phenotype of Scer\GAL4^repo.PU, kon^{UAS.Tag:HA,Tag:SS(wg)}

(Harrison et al., 2021)

NOT Suppressor of

Statement

Reference

Scer\GAL4^elav.PU/eya^JF03160 is a non-suppressor of larval ventral nerve cord phenotype of Scer\GAL4^elav.PU, kon^{UAS.Tag:HA,Tag:SS(wg)}

(Harrison et al., 2021)

Other

Statement

Reference

Scer\GAL4^esg-MH766, Scer\GAL80^ey.3.5, eya^JF03160, so^KK108128 has embryonic/larval optic lobe | third instar larval stage phenotype

(Apitz and Salecker, 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Simultaneous expression of eya^JF03160 and so^KK108128 under the control of Scer\GAL4^esg-MH766 combined with Scer\GAL80^ey.3.5 leads to mispositioned neuroblast/ganglion mother cell clusters in the medulla cortex or expansion of areas containing these cells in third instar larval brain compared t controls.

(Apitz and Salecker, 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

28733

y¹ v¹; P{TRiP.JF03160}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

eya<up>IR JF03160</up>

(Apitz and Salecker, 2016)

eya^JF03160

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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