FB2024_03 , released June 25, 2024
Allele: Dmel\incKK108908
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General Information
Symbol
Dmel\incKK108908
Species
D. melanogaster
Name
FlyBase ID
FBal0235916
Feature type
allele
Associated gene
Dmel\inc
Associated Insertion(s)
Carried in Construct
P{KK108908}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
in vitro construct
(Keleman et al., 2009.8.5)
Progenitor genotype
Carried in construct
P{KK108908}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-KK108908
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of incKK108908 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to enhance RNAi effects) results in sleep defects: the flies show a reduction in sleep duration compared to controls, with a reduction in the average sleep bout length.

      Expression of incKK108908 under the control of Scer\GAL430Y (in the presence of Dcr-2Scer\UAS.cDa to enhance RNAi effects) has no affect on sleep.

      Expression of incKK108908 under the control of Scer\GAL4elav.Switch.PO during development (using RU486 to control the timing of expression) results in reduced sleep duration, while expression of incKK108908 under the control of Scer\GAL4elav.Switch.PO during the adult stage only does not result in sleep defects.

      (Pfeiffenberger and Allada, 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of both incKK108908 and Cul-3NIG.11861R under the control of Scer\GAL430Y (in the presence of Dcr-2Scer\UAS.cDa to enhance RNAi effects) results in a significant decrease in sleep duration and average sleep bout length.

      (Pfeiffenberger and Allada, 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CG32810KK108908
      incKK108908
      Name Synonyms
      Secondary FlyBase IDs
        References (2)