FlyBase Allele Report: Dmel\Miro[KK102189]

Third instar larvae expressing Miro^KK102189 under the control of Scer\GAL4^CCAP.PP show a severe decrease in both anterograde and retrograde axonal transport of mitochondria, as compared to controls.

(Tsai et al., 2017)

Embryos derived from females expressing Miro^KK102189 under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} show an increase in ventral midline cell division at the end of germband shortening. The mutant embryos show an average of 11.1 mitotic cells in total in the 10 trunk neuromeres (compared to 4.8 cells in wild type).

(Bossing et al., 2012)

Expression of Miro^KK102189 under the control of Scer\GAL4^elav.PU results in an increase in mitochondrial content in adult neuronal cell bodies. However these mitochondria do not display any morphology defects. Mitochondrial length is similar to controls.

(Duboff et al., 2012)

Expression of Miro^KK102189 in eyes under the control of Scer\GAL4^GMR.PF results in loss of mitochondria in the synaptic terminals of the photoreceptor neurons. Degeneration is seen in the lamina of 40 day old flies.

(Iijima-Ando et al., 2012)

Expression of Miro^KK102189 under the control of Scer\GAL4^ple.PF in larval motor neurons results in decreased axonal mitochondrial transport flux and velocity in both anterograde and retrograde directions, decreased mitochondrial length, and decreased accumulation of mitochondria in the most distal boutons of neuromuscular junctions, as compared with controls.

(Liu et al., 2012)

Glial cells show mis-distribution of mitochondria in third instar larvae expressing Miro^KK102189 under the simultaneous control of both Scer\GAL4^repo.PL and Scer\GAL4^repo.

(Schmidt et al., 2012)

Expression of Miro^KK102189 in ddaE neuronal soma under the control of Scer\GAL4^elav-C155 reduces by 50% the number of mitochondria in the dorsal comb-like dendrite. Severed dendrites lacking mitochondria are completely removed by 12-18 hours, as in controls.

(Tao and Rolls, 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Miro^KK102189, Scer\GAL4^GMR.PF is an enhancer of abnormal neuroanatomy | adult stage | conditional phenotype of Hsap\MAPT^UAS.cWa, Scer\GAL4^GMR.PF

(Iijima-Ando et al., 2012)

Suppressor of

Statement

Reference

Miro^KK102189, Scer\GAL4^Mhc.PW is a suppressor | partially of visible phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW, rictor^Δ2

(Wu et al., 2013)

Miro^KK102189, Scer\GAL4^Mhc.PW is a suppressor | partially of visible phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW, trc^{K122A.UAS.L.Tag:FLAG}

(Wu et al., 2013)

Scer\GAL4^Mhc.PU/Miro^KK102189 is a suppressor | partially of visible phenotype of Pink1^B9

(Liu et al., 2012)

Scer\GAL4^Mhc.PU/Miro^KK102189 is a suppressor | partially of abnormal flight phenotype of Pink1^B9

(Liu et al., 2012)

Scer\GAL4^ple.PF/Miro^KK102189 is a suppressor of abnormal neuroanatomy | adult stage phenotype of Pink1^B9

(Liu et al., 2012)

Phenotype Manifest In

Enhancer of

Statement

Reference

Miro^KK102189, Scer\GAL4^GMR.PF is an enhancer of lamina phenotype of Hsap\MAPT^UAS.cWa, Scer\GAL4^GMR.PF

(Iijima-Ando et al., 2012)

Suppressor of

Statement

Reference

Miro^KK102189, Scer\GAL4^Mhc.PW is a suppressor | partially of wing phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW, rictor^Δ2

(Wu et al., 2013)

Miro^KK102189, Scer\GAL4^Mhc.PW is a suppressor | partially of wing phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW, trc^{K122A.UAS.L.Tag:FLAG}

(Wu et al., 2013)

Scer\GAL4^Mhc.PU/Miro^KK102189 is a suppressor | partially of wing phenotype of Pink1^B9

(Liu et al., 2012)

Scer\GAL4^ple.PF/Miro^KK102189 is a suppressor of dopaminergic PPL1 neuron phenotype of Pink1^B9

(Liu et al., 2012)

Scer\GAL4^ple.PF/Miro^KK102189 is a suppressor of mitochondrion | adult stage phenotype of Pink1^B9

(Liu et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

The ability of rictor^Δ2 to enhance the abnormal wing posture phenotype seen in flies expressing Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PW is partially suppressed by co-expression of Miro^KK102189.

The ability of trc^{K122A.Scer\UAS.T:Zzzz\FLAG} to enhance the abnormal wing posture phenotype seen in flies expressing Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PW is partially suppressed by co-expression of Miro^KK102189.

(Wu et al., 2013)

Expression of Miro^KK102189 under the control of Scer\GAL4^Mhc.PU partially rescues the abnormal wing posture and flight defects of Pink1^B9/Pink1^B9 mutants.

Expression of Miro^KK102189 under the control of Scer\GAL4^ple.PF rescues the dopaminergic neuron loss and mitochondrial aggregation phenotypes of Pink1^B9/Pink1^B9 mutant adults.

(Liu et al., 2012)

Xenogenetic Interactions

Statement

Reference

Expression of Miro^KK102189 enhances neurodegeneration in the lamina of 3 day old flies expressing Hsap\MAPT^Scer\UAS.cWa under the control of Scer\GAL4^GMR.PF.

(Iijima-Ando et al., 2012)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v106683

P{KK102189}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Miro^KK102189

miro^dsRNA

(Schmidt et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (16)

Report Sections

Open Close