FlyBase Allele Report: Dmel\dnd[1]

General Information

Symbol

Dmel\dnd¹

Species

D. melanogaster

Name

FlyBase ID

FBal0230405

Feature type

allele

Associated gene

Dmel\dnd

Associated Insertion(s)

Carried in Construct

Also Known As

Arl3¹

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

P-element activity

Nature of the Allele

Allele class

loss of function allele

(Kakihara et al., 2008)

Mutagen

P-element activity

(Kakihara et al., 2008)

Progenitor genotype

P{XP}CG6678^d10234

(Kakihara et al., 2008)

Caused by aberration

Df(3R)Arl3¹

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:21,886,826..21,887,505 [-]

Comment:

Mutation caused by Df(3R)Arl3¹, which removes 680 bp including the initiator MET of dnd and some of the overlapping 5' UTR of CG6678.

(Kakihara et al., 2008)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | dominant

(Kakihara et al., 2008)

Phenotype Manifest In

dorsal tracheal branch primordium

(Kakihara et al., 2008)

extracellular vesicle | absent | embryonic stage

(Camelo et al., 2022)

tracheal branch primordium

(Camelo et al., 2022)

tracheal dorsal trunk primordium

(Kakihara et al., 2008)

tracheal dorsal trunk primordium (with Df(3R)e-GC3)

(Kakihara et al., 2008)

tracheal dorsal trunk primordium | embryonic stage

(Caviglia et al., 2016)

Detailed Description

Statement

Reference

dnd¹/dnd¹ mutant embryos display defects in dorsal trunk tube fusion.

(Caviglia et al., 2016)

The frequency of successful tracheal cell fusions is decreased in embryonic dorsal branches of heterozygous dnd¹/+ embryos compared to wild-type.

Homozygous dnd¹ or hemizygous dnd¹/Df(3R)e-GC3 embryos show a tracheal disconnection phenotype in the dorsal trunk at high frequency. The failure of fusion is more severe in the embryonic dorsal branches.

In dnd¹ mutants, the tips of the tracheal lumen shifted and became tightly apposed to each other in a manner similar to wild-type embryos, but remained unconnected.

(Kakihara et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

dnd¹ has visible | dominant phenotype, enhanceable by Sec5^E10/sec5[+]

(Kakihara et al., 2008)

Enhancer of

Statement

Reference

dnd¹/dnd[+] is an enhancer of visible | dominant phenotype of Sec5^E10

(Kakihara et al., 2008)

Phenotype Manifest In

Enhanced by

Statement

Reference

dnd¹ has dorsal tracheal branch primordium phenotype, enhanceable by Sec5^E10/sec5[+]

(Kakihara et al., 2008)

NOT Enhanced by

Statement

Reference

dnd¹ has tracheal branch primordium phenotype, non-enhanceable by stac^3B20

(Camelo et al., 2022)

Suppressed by

Statement

Reference

dnd¹ has tracheal dorsal trunk primordium | embryonic stage phenotype, suppressible | partially by Scer\GAL4^btl.PU/stac^UAS.A.EGFP

(Caviglia et al., 2016)

dnd¹ has tracheal dorsal trunk primordium | embryonic stage phenotype, suppressible | partially by Scer\GAL4^btl.PU/Rab39^UASp.YFP

(Caviglia et al., 2016)

NOT suppressed by

Statement

Reference

dnd¹ has tracheal dorsal trunk primordium | embryonic stage phenotype, non-suppressible by Scer\GAL4^btl.PU/Rab7^UASp.YFP

(Caviglia et al., 2016)

Enhancer of

Statement

Reference

dnd¹ is an enhancer of dorsal tracheal branch primordium phenotype of Sec5^E10

(Kakihara et al., 2008)

NOT Enhancer of

Statement

Reference

dnd¹ is a non-enhancer of tracheal branch primordium phenotype of stac^3B20

(Camelo et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of stac^{Scer\UAS.A.T:Avic\GFP-EGFP} or Rab39^{Scer\UAS.P\T.T:Avic\GFP-YFP}, but not Rab7^{Scer\UAS.P\T.T:Avic\GFP-YFP}, under the control of Scer\GAL4^btl.PU partially rescues the tracheal fusion defects of dnd¹/dnd¹ mutant embryos.

(Caviglia et al., 2016)

Compound heterozygotes of sec5^E10 and dnd¹ exhibit a significant enhancement of the DB fusion phenotype compared with each single mutation.

(Kakihara et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

dnd¹ is rescued by Scer\GAL4^btl.PS/dnd^UAS.cKa

(Kakihara et al., 2008)

dnd¹ is rescued by Scer\GAL4^btl.PS/dnd^Q71L.UAS

(Kakihara et al., 2008)

Partially rescued by

dnd¹ is partially rescued by dnd^T31N.UAS/Scer\GAL4^btl.PS

(Kakihara et al., 2008)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

dnd protein is undetectable in homozygous dnd¹ embryos.

(Kakihara et al., 2008)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Arl3¹

(Camelo et al., 2022, Caviglia et al., 2016, Kakihara et al., 2008)

arl3¹

(Kato et al., 2016)

dnd¹

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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