FlyBase Allele Report: Dmel\Trpml[2]

General Information

Symbol

Dmel\Trpml²

Species

D. melanogaster

Name

FlyBase ID

FBal0221783

Feature type

allele

Associated gene

Dmel\Trpml

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Venkatachalam et al., 2008)

Progenitor genotype

P{EP}Trpml^GE22279

(Venkatachalam et al., 2008)

Cytology

Description

Imprecise excision of the progenitor insertion, resulting in a 1.1kb deletion which removes nucleotides -234 to +860 relative to the trpml translation start site.

(Venkatachalam et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:19,717,208..19,718,068 [-]

Comment:

Imprecise excision of the progenitor insertion, resulting in a 1.1kb deletion which removes nucleotides -234 to +860 relative to the Trpml translation start site.

(Venkatachalam et al., 2008)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | third instar larval stage

(Wong et al., 2015)

abnormal neuroanatomy | third instar larval stage (with Trpml¹)

(Wong et al., 2015)

lethal - all die before end of pupal stage (with Trpml¹)

(Venkatachalam et al., 2008)

lethal - all die before end of pupal stage | recessive

(Venkatachalam et al., 2008)

some die during pupal stage (with Trpml¹)

(Venkatachalam et al., 2008)

some die during pupal stage | recessive

(Venkatachalam et al., 2008)

Phenotype Manifest In

embryonic/larval neuromuscular junction | third instar larval stage

(Wong et al., 2015)

embryonic/larval neuromuscular junction | third instar larval stage (with Trpml¹)

(Wong et al., 2015)

NMJ bouton | third instar larval stage

(Wong et al., 2015)

NMJ bouton | third instar larval stage (with Trpml¹)

(Wong et al., 2015)

Detailed Description

Statement

Reference

Trpml²/Trpml² and Trpml¹/Trpml² third instar larvae display fewer neuromuscular junction boutons compared to wild-type controls.

(Wong et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Trpml² is a suppressor | partially of lethal - all die during P-stage phenotype of AMPKα^JF01951, Scer\GAL4^Act.PU

(Onyenwoke et al., 2015)

Trpml² is a suppressor of lethal - all die during P-stage | recessive phenotype of AMPKα¹

(Onyenwoke et al., 2015)

Trpml² is a suppressor of lethal - all die during P-stage | recessive phenotype of AMPKα³

(Onyenwoke et al., 2015)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

The late pupal lethality observed in animals expressing AMPKα^JF01951 under the control of Scer\GAL4^Act.PU can be partially rescued by combination with either Trpml¹ or Trpml².

The pupal-stage lethality of either hemizygous AMPKα¹ or AMPKα³ males can be partially rescued by combination with either Trpml¹ or Trpml².

(Onyenwoke et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Trpml¹/Trpml² is rescued by Trpml^+tVa

(Venkatachalam et al., 2008)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

42230

w^*; Trpml²/TM6B, Tb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

MCOLN²

(Onyenwoke et al., 2015)

Trpml²

trpml²

(Dhakal et al., 2022, Ma and Freeman, 2020, Rimal and Lee, 2019, Onyenwoke et al., 2015, Wong et al., 2015, Venkatachalam et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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