FlyBase Allele Report: Dmel\Hmr[Df]

General Information

Symbol

Dmel\Hmr^Df

Species

D. melanogaster

Name

FlyBase ID

FBal0221202

Feature type

allele

Associated gene

Dmel\Hmr

Associated Insertion(s)

Carried in Construct

Also Known As

Df(1)Hmr^-

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Barbash and Lorigan, 2007)

Progenitor genotype

Hmr¹

(Barbash and Lorigan, 2007)

Cytology

Description

Imprecise excision of the insertion in Hmr¹, resulting in a 600bp deletion (plus a 25bp insertion of non-homologous sequences) that extends from the insertion site towards Hmr and removes the first 95 codons (and first 2bp of the 96th codon) of Hmr.

(Barbash and Lorigan, 2007)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female semi-sterile (with Hmr²)

(Aruna et al., 2009)

female semi-sterile | progressive, with Hmr^dC.t9.5

(Lukacs et al., 2021)

female semi-sterile | recessive

(Aruna et al., 2009)

Phenotype Manifest In

dorsal appendage

(Aruna et al., 2009)

egg

(Aruna et al., 2009)

Detailed Description

Statement

Reference

Hmr^Df/Hmr^Df females show reduced viability and fertility when maintained at 27[o]C.

Hmr²/Hmr^Df females have significantly reduced fertility compared to controls.

At 28[o]C, homozygous females aged 3-4 days or 9-10 days lay significantly fewer eggs than controls. Eggs laid from 3-4 day old homozygous females also hatch into larvae and produce eclosed adults at lower frequencies than those of control siblings. The eggs laid by the homozygous females are slightly mis-shapen and have shorter chorionic appendages than those laid by controls. The appendages are often fused at their tips, but the spacing at the base appears normal.

(Aruna et al., 2009)

Hmr^Df rescues the lethality of hybrid males derived from a cross of D.melanogaster females to D.simulans males.

(Barbash and Lorigan, 2007)

Hmr^Df can fully rescue the viability of hybrid males that are derived from a cross of D.melanogaster females to D.simulans males.

(Barbash, 2007)

Hybrid males derived from a cross of D. melanogaster females and D. simulans males and rescued by the presence of Hmr^Df have a near normal proportion of mitotic figures in anaphase/telophase in the larval brain compared to the pure-species controls, but the mitotic index remains somewhat lower than that of the controls in the hybrid males. In addition, chromosome morphology in the brains of rescued hybrid male larvae is often unusually elongated and stringy. Hybrid females derived from a cross of D. melanogaster females and D. simulans males and carrying Hmr^Df show normal mitotic progression and chromosome condensation in the larval brain.

(Bolkan et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Dsim\Lhr^T:Ivir\HA1 has little effect on the viability of hybrid Hmr^Df males (progeny of Hmr^Df Dsim\Lhr^T:Ivir\HA1 D. melanogaster females mated to either D. simulans or D. mauritiana males).

Lhr^T:Ivir\HA1 has little effect on the viability of hybrid Hmr^Df males (progeny of Hmr^Df Lhr^T:Ivir\HA1 D. melanogaster females mated to either D. simulans or D. mauritiana males).

(Maheshwari and Barbash, 2012)

The reduced viability of Hmr^Df/Hmr^Df females that is seen at 27[o]C is not rescued by Dsim\Hmr^+t8.6 or Dmau\Hmr^+t9.4, while the reduced fertility phenotype of Hmr^Df/Hmr^Df females is partially complemented by Dsim\Hmr^+t8.6 or Dmau\Hmr^+t9.4.

(Aruna et al., 2009)

The ability of Hmr^Df to rescue the viability of hybrid males derived from of a cross of D.melanogaster females to D.simulans males or from a cross of D.melanogaster females to D.sechellia males is completely suppressed by Nup98^E53.1.

The ability of Hmr^Df to rescue the viability of hybrid males derived from of a cross of D.melanogaster females to D.mauritiana males is not affected by Nup98^E53.1.

(Barbash, 2007)

Complementation and Rescue Data

Rescued by

Hmr^Df is rescued by Hmr^Tag:FLAG

(Satyaki et al., 2014)

Hmr^Df is rescued by Hmr^Tag:HA

(Satyaki et al., 2014)

Hmr^Df is rescued by Hmr^+tp72

(Aruna et al., 2009)

Comments

Hmr^T:Zzzz\FLAG suppresses the ability of Hmr^Df to rescue the lethality of hybrid male progeny of a cross between Hmr^Df D. melanogaster females to D. simulans males, indicating that Hmr^T:Zzzz\FLAG is Hmr[+].

Hmr^T:Ivir\HA1 suppresses the ability of Hmr^Df to rescue the lethality of hybrid male progeny of a cross between Hmr^Df D. melanogaster females to D. simulans males, indicating that Hmr^T:Ivir\HA1 is Hmr[+].

(Satyaki et al., 2014)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Df(1)Hmr-

(Lukacs et al., 2021)

Df(1)Hmr^-

(Satyaki et al., 2014, Maheshwari and Barbash, 2012, Aruna et al., 2009, Barbash, 2007, Barbash and Lorigan, 2007, Bolkan et al., 2007, Brideau et al., 2006)

Hmr^Df

Hmr^ko

(Lukacs et al., 2021)

Name Synonyms

Secondary FlyBase IDs

FBab0045117

References (8)

Report Sections

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