FlyBase Allele Report: Dmel\Hmr[1]

General Information

Symbol

Dmel\Hmr¹

Species

D. melanogaster

Name

FlyBase ID

FBal0005499

Feature type

allele

Associated gene

Dmel\Hmr

Associated Insertion(s)

P{}Hmr¹

Carried in Construct

Also Known As

Hmr

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

natural population

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Barbash et al., 2003)

Mutagen

natural population

(Hutter et al., 1990, Hutter and Ashburner, 1987)

Progenitor genotype

Associated Insertion(s)

P{}Hmr¹

Cytology

No chromosome abnormalities are shown.

Description

A 653bp internally truncated P-element is inserted 32bp 5' of the Hmr gene.

(Barbash et al., 2003)

The P-element present on the Hmr¹ chromosome is a defective 652bp P-element that is inserted 525bp upstream of the 5' end of CG1628.

(Hutter, 2002)

This allele may be caused by a P-element insertion, since P-element probes hybridise to the region where Hmr is thought to be located in chromosomes carrying Hmr¹.

(Hutter et al., 1990)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:10,595,848..10,595,848 [-]

(Barbash et al., 2003)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Hmr¹ suppresses hybrid male lethality of hybrid sons of crosses between D.melanogaster females and D.mauritiana males. This hybrid rescue is not suppressed if the hybrids also carry Dsim\Hmr^+t8.6 or Dmau\Hmr^+t9.4.

(Barbash et al., 2004)

Essentially no rescue of fertility is seen in female hybrids derived from a cross of Hmr¹ D.melanogaster females mated to D.simulans males.

(Barbash and Ashburner, 2003)

Hybrid daughters from a cross of D.melanogaster females to D.simulans or D.sechellia males are poorly viable at high temperatures. This female lethality is suppressed by D.melanogaster Hmr¹, although rescue is partial at 29^oC. Hybrid males from a cross of D.melanogaster females to D.simulans males are not viable. This male lethality is rescued by D.melanogaster Hmr¹ at 18^oC but not at 27^oC. Hybrid males from a cross of D.melanogaster females to D.sechellia males are not viable. D.melanogaster Hmr¹ shows low rescue of this male lethality at 18^oC and no rescue at higher temperatures. Hybrid daughters (from a cross of D.melanogaster females to D.simulans males) that carry two D.melanogaster X chromosomes are lethal. This lethality is partially suppressed by one copy of D.melanogaster Hmr¹. Hybrid daughters (from a cross of D.melanogaster females to D.mauritiana males) that carry two D.melanogaster X chromosomes are lethal. This lethality is not suppressed by one copy of D.melanogaster Hmr¹. Hybrid females from a cross of D.simulans females to D.melanogaster males are poorly viable. The lethality of these hybrids (which is embryonic) is rescued by D.simulans Dsim\mhr¹. These rescued hybrids also show postembryonic lethality at 25^oC. This postembryonic lethality is suppressed by D.melanogaster Hmr¹.

(Barbash et al., 2000)

Hmr¹ rescues D.melanogaster/D.mauritiana hybrid males (derived from a cross of D.melanogaster females to D.mauritiana males) that would normally be inviable. Hmr¹ weakly rescues (in some genetic backgrounds) D.melanogaster/D.simulans hybrid males (derived from a cross of D.melanogaster females to D.simulans males) that would normally be inviable.

(Orr and Irving, 2000)

Hmr¹ rescues hybrid males from a cross between D.melanogaster Hmr¹ females and D.mauritiana males. The frequency of spontaneous chromosome loss is similar to that seen in a cross between D.melanogaster Hmr⁺ females and D.mauritiana males. Hmr¹ rescues the mitotic chromosome decondensation defect seen in the larval brain neuroblasts of male hybrids produced from a cross between D.melanogaster females and D.mauritiana males.

(Orr et al., 1997)

Hemizygous males, homozygous females and Hmr¹/Df(1)HC133 females are indistinguishable from wild-type flies in their appearance, viability and fertility. This allele rescues hybrid males (that would otherwise die) from a cross of D.melanogaster females to either D.simulans, D.mauritiana or D.sechellia males. Hybrid males (produced from a cross between D.melanogaster females and D.mauritiana males) are not rescued by a duplication thought to carry Hmr⁺ (Dp(1;2)v⁺75d), so the rescue is considered to be recessive. Inviable female hybrids from crosses of compound-X D.melanogaster females to either D.simulans, D.mauritiana or D.sechellia males are also rescued. This rescue is also recessive, since a compound-X chromosome heterozygous for Hmr¹ does not rescue.

(Hutter et al., 1990)

Rescues D.melanogaster/simulans hybrid males that would otherwise be inviable. These hybrids are sterile. It has no effect on the low viability of hybrid females from a cross of D.simulans females to D.melanogaster males. Hybrids from crosses of D.melanogaster females to either D.mauritiana or D.sechellia males that would be otherwise inviable are also rescued. The rescue of D.melanogaster/simulans and D.melanogaster/mauritiana males is almost complete at 18^oC. The rescue of D.melanogaster/mauritiana males is good at 25^oC but not at 29^oC. The rescue of D.melanogaster/simulans males is severely depressed at 25^oC. Only one third of D.melanogaster/sechellia males survive to adulthood at 18^oC. The temperature-sensitive period for hybrid rescue is in the second larval instar.

(Hutter and Ashburner, 1987)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Hmr¹ has phenotype, non-suppressible by Rab9D^tp72

(Barbash et al., 2003)

Hmr¹ has phenotype, non-suppressible by CG2124^tp72

(Barbash et al., 2003)

Hmr¹ has phenotype, non-suppressible by Ant2^t10.3

(Zhang et al., 1999)

Hmr¹ has phenotype, non-suppressible by sesB^+t10.3

(Zhang et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

(Barbash et al., 2004)

The hybrid male rescue activity of Hmr¹ is not suppressed by Rab9D^tp72 or CG2124^tp72.

(Barbash et al., 2003)

The hybrid rescue by Hmr¹ of the male progeny of D.melanogaster females crossed to D.mauritiana males is not suppressed by P{Ant2⁺sesB⁺10.3}.

(Zhang et al., 1999)

Xenogenetic Interactions

Statement

Reference

Hybrid Hmr¹ males (progeny of Hmr¹ Dsim\Lhr^T:Ivir\HA1 D. melanogaster females mated to D. mauritiana males) carrying Dsim\Lhr^T:Ivir\HA1 are essentially inviable at room temperature and show strongly reduced viability (compared to hybrid Hmr¹ males not carrying Dsim\Lhr^T:Ivir\HA1) at 18[o]C.

Hybrid Hmr¹ males (progeny of Hmr¹ Lhr^T:Ivir\HA1 D. melanogaster females mated to D. mauritiana males) carrying Lhr^T:Ivir\HA1 show 32-44% viability at room temperature and 52-69% viability at 18[o]C (compared to hybrid Hmr¹ males not carrying Lhr^T:Ivir\HA1).

Hybrid Hmr¹ males (progeny of Hmr¹ Dsim\Lhr^2.T:Ivir\HA1 D. melanogaster females mated to D. mauritiana males) carrying Dsim\Lhr^2.T:Ivir\HA1 are fully viable at 18[o]C and have substantially higher viability (138.8-144.3%) at room temperature compared to hybrid Hmr¹ male siblings not carrying Dsim\Lhr^2.T:Ivir\HA1.

Hybrid Hmr¹ males (progeny of Hmr¹ Dsim\Lhr^{2+Cter.T:Ivir\HA1} D. melanogaster females mated to D. mauritiana males) carrying Dsim\Lhr^{2+Cter.T:Ivir\HA1} are essentially inviable at room temperature and show strongly reduced viability (compared to hybrid Hmr¹ males not carrying Dsim\Lhr^{2+Cter.T:Ivir\HA1}) at 18[o]C.

Hybrid Hmr¹ males (progeny of Hmr¹ Dsim\Lhr^{2+16aa.T:Ivir\HA1} D. melanogaster females mated to D. mauritiana males) carrying Dsim\Lhr^{2+16aa.T:Ivir\HA1} are fully viable at room temperature and show 81-84% viability at 18[o]C (compared to hybrid Hmr¹ male siblings not carrying Dsim\Lhr^{2+16aa.T:Ivir\HA1}).

(Maheshwari and Barbash, 2012)

Hybrid Hmr¹ males (progeny of Hmr¹ Dsim\Lhr^T:Ivir\HA1 D. melanogaster females mated to either D. simulans or D. mauritiana males) carrying Dsim\Lhr^T:Ivir\HA1 are essentially inviable at room temperature and show strongly reduced viability (compared to hybrid Hmr¹ males not carrying Dsim\Lhr^T:Ivir\HA1) at 18[o]C.

Lhr^T:Ivir\HA1 reduces the viability of hybrid Hmr¹ males (progeny of Hmr¹ Lhr^T:Ivir\HA1 D. melanogaster females mated to either D. simulans or D. mauritiana males).

(Maheshwari and Barbash, 2012)

Rescue of D.simulans-D.melanogaster hybrids by the Hmr¹ mutation is suppressed by expression of Dsim\Lhr^Scer\UAS.cBa under the control of Scer\GAL4^unspecified.

(Brideau et al., 2006)

Complementation and Rescue Data

Rescued by

Hmr¹ is rescued by Hmr^+tp83

(Barbash et al., 2003)

Hmr¹ is rescued by Hmr^+tp72

(Barbash et al., 2003)

Hmr¹ is rescued by Hmr^+tp74

(Barbash et al., 2003)

Not rescued by

Hmr¹ is not rescued by Hmr^tp73

(Barbash et al., 2003)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

2481

Hmr¹

1935

y¹ Hmr¹ v¹

Notes on Origin

Discoverer

Isolated from: Uman', Ukraine population, 1979.

(Hutter et al., 1990, Hutter and Ashburner, 1987)

Comments

In Hmr¹ flies, the Rab9D gene contains five nucleotide changes, which lead to four amino acid substitutions.

(Hutter, 2005.7.25)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Hmr

(Hutter, 2002, Orr and Irving, 2000, Orr et al., 1997, Hutter et al., 1990, Hutter and Ashburner, 1987)

Hmr1

(Hutter, 2005.7.25)

Hmr¹

(Kotov et al., 2019, Thomae et al., 2013, Maheshwari and Barbash, 2012, Maheshwari and Barbash, 2012, Aruna et al., 2009, Brideau et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (19)

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