FlyBase Allele Report: Dmel\Bx[D110]

General Information

Symbol

Dmel\Bx^D110

Species

D. melanogaster

Name

FlyBase ID

FBal0220814

Feature type

allele

Associated gene

Dmel\Bx

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Biryukova et al., 2009, Asmar et al., 2008)

Progenitor genotype

P{EPgy2}EY01065

(Biryukova et al., 2009, Asmar et al., 2008)

Cytology

Description

Imprecise excision of the P{EPgy2}EY01065 insertion, resulting in a deletion that includes Bx 3' UTR sequences (proximal deletion breakpoint is within the Bx 3'UTR.

(Biryukova et al., 2009)

Imprecise excision of the progenitor insertion, resulting in deletion of 64% of the sequence encoding the Bx 3' UTR. The coding sequence is unaffected.

(Asmar et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible (with Bx^MS1096)

(Biryukova et al., 2009)

visible | dominant

(Biryukova et al., 2009, Asmar et al., 2008)

Phenotype Manifest In

dorsocentral bristle | increased number

(Asmar et al., 2008)

wing

(Biryukova et al., 2009)

wing (with Bx^MS1096)

(Biryukova et al., 2009)

wing margin

(Asmar et al., 2008)

wing margin bristle | increased number

(Asmar et al., 2008)

Detailed Description

Statement

Reference

Heterozygotes have extreme wing defects.

(Biryukova et al., 2009)

Mutants show loss of wing margin. Extra dorsocentral bristles are present on the notum and there are extra sensory bristles on the residual anterior wing margins.

(Asmar et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Bx^MS1096/Bx^D110 has visible phenotype, non-suppressible by mir-9a^UAS.cBa/Scer\GAL4^Bx-MS1096

(Biryukova et al., 2009)

Enhancer of

Statement

Reference

Bx^D110 is an enhancer of visible phenotype of Chi^E

(Asmar et al., 2008)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Bx^MS1096/Bx^D110 has wing phenotype, non-suppressible by mir-9a^UAS.cBa/Scer\GAL4^Bx-MS1096

(Biryukova et al., 2009)

Enhancer of

Statement

Reference

Bx^D110 is an enhancer of dorsocentral bristle phenotype of Chi^E

(Asmar et al., 2008)

Bx^D110 is an enhancer of adult thorax phenotype of Chi^E

(Asmar et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

The wing defects seen in Bx^D110/Bx^MS1096 flies are not affected by expression of mir-9a^Scer\UAS.cBa under the control of Scer\GAL4^Bx-MS1096.

(Biryukova et al., 2009)

The Chi^E homozygous phenotype of loss of dorsocentral bristles and presence of a slight thoracic cleft is enhanced by hemizygosity for Bx^D110.

The mutant wing phenotypes of Bx^D110 and Chi^E are mutually suppressed in Bx^D110/+ ; Chi^E flies.

(Asmar et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Bx^D110

(Biryukova et al., 2009, Asmar et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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