FB2024_03 , released June 25, 2024
Allele: Dmel\Taf62
Open Close
General Information
Symbol
Dmel\Taf62
Species
D. melanogaster
Name
FlyBase ID
FBal0219553
Feature type
allele
Associated gene
Dmel\Taf6
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: W128R.

    (Aoyagi and Wassarman, 2001)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3L:19,599,583..19,599,583 [+]
    Nucleotide change:

    T19599583C

    Amino acid change:

    W142R | Taf6-PA; W142R | Taf6-PB

    Reported amino acid change:

    W128R

    (Aoyagi and Wassarman, 2001)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Taf6XS-922/Taf62 animals rescued to adulthood by expression of Taf6hs.T:Zzzz\FLAG have notched wing and rough eye phenotypes, which are less severe if the animals are heat shocked during adulthood to express Taf6hs.T:Zzzz\FLAG.

        Taf6XS-922/Taf62 males rescued to adulthood by expression of Taf6hs.T:Zzzz\FLAG (including heat shock during the adult stage) have postmeiotic stages including mature spermatids in the testis, but they are less abundant than in wild type. Taf6XS-922/Taf62 males rescued to adulthood by expression of Taf6hs.T:Zzzz\FLAG with no heat shock during the adult stage have a more severe phenotype; proliferation of stem cells to primary spermatocytes is normal, but the primary spermatocytes occupy an abnormally large portion of the testis and degenerate without initiating meiotic chromosome condensation.

        (Aoyagi and Wassarman, 2001)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Partially rescued by

        Taf62/Taf61 is partially rescued by Taf6hs.Tag:FLAG

        (Aoyagi and Wassarman, 2001)

        Taf62/Taf6XS-922 is partially rescued by Taf6hs.Tag:FLAG

        (Aoyagi and Wassarman, 2001)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        TAFII602
        (Aoyagi and Wassarman, 2001)
        Taf62
        (Vázquez et al., 2008)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)