FB2024_03 , released June 25, 2024
Allele: Dmel\EgfrAct.cUa.UAS
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General Information
Symbol
Dmel\EgfrAct.cUa.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0219093
Feature type
allele
Associated gene
Dmel\Egfr
Associated Insertion(s)
Carried in Construct
P{UAS-Egfr.Act.U}
Also Known As
UAS-EGFRCA, UAS-EgfrAct
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Overton et al., 2007)
Progenitor genotype
Carried in construct
P{UAS-Egfr.Act.U}
Cytology
Description

UAS regulatory sequences drive expression of activated Egfr.

(Overton et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Egfr
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  high grade glioma
      CEA with Pi3K92ECAAX.UAS
      (Pryszlak et al., 2021)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Larvae expressing EgfrAct.cUa.Scer\UAS under the control of Scer\GAL4sca.PU results in the formation of three to 4 rows of ectopic denticles posterior to the wild-type row 6 denticles.

      (Overton et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      EgfrAct.cUa.UAS, Scer\GAL4sca.PU has denticle | ectopic phenotype, suppressible by SoxNGA1192

      (Overton et al., 2007)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The ectopic denticle formation seen in larvae expressing EgfrAct.cUa.Scer\UAS under the control of Scer\GAL4sca.PU is strongly reduced by SoxNGA1192.

      (Overton et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      EgfrAct.cUa.Scer\UAS
      EgfrAct.cUa.UAS
      EgfrCA
      (Zhao et al., 2022)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)