FlyBase Allele Report: Dmel\NimC4[UAS.GFP]

General Information

Symbol

Dmel\NimC4^UAS.GFP

Species

D. melanogaster

Name

FlyBase ID

FBal0218197

Feature type

allele

Associated gene

Dmel\NimC4

Associated Insertion(s)

Carried in Construct

P{UAS-NimC4-GFP}

Also Known As

UASsimu

Key Links

Transgenic product class

wild_type

(Kurant et al., 2008)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Kurant et al., 2008)

Mutagen

in vitro construct

(Kurant et al., 2008)

Progenitor genotype

Carried in construct

P{UAS-NimC4-GFP}

Cytology

Description

UAS regulatory sequences drive expression of NimC4 tagged with GFP.

(Kurant et al., 2008)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

NimC4

Tagged with

GFP

green fluorescent protein

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^repo.PU/NimC4^UAS.GFP is a suppressor of abnormal neuroanatomy | embryonic stage phenotype of repo⁰³⁷⁰²

(Shklyar et al., 2014)

drpr^I.UAS, Scer\GAL4^repo.PU, NimC4^UAS.GFP is a suppressor of abnormal neuroanatomy | embryonic stage phenotype of repo⁰³⁷⁰²

(Shklyar et al., 2014)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^repo.PU/NimC4^UAS.GFP is a suppressor | partially of glial cell phenotype of repo⁰³⁷⁰²

(Shklyar et al., 2014)

drpr^I.UAS, Scer\GAL4^repo.PU, NimC4^UAS.GFP is a suppressor of glial cell phenotype of repo⁰³⁷⁰²

(Shklyar et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of NimC4^{Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^repo.PU partially rescues the phagocytosis defects seen in repo⁰³⁷⁰² mutant embryos. The morphology and localisation of the glia still appear abnormal and the cells are overloaded with apoptotic particles. However, although the total volume of apoptotic particles in the CNS remains the same as in repo⁰³⁷⁰² mutant embryos alone, a higher proportion have been engulfed by phagocytes in the rescue embryos.

Co-expression of NimC4^{Scer\UAS.T:Avic\GFP} and drpr^I.Scer\UAS under the control of Scer\GAL4^repo.PU fully rescues the phagocytosis defects seen in repo⁰³⁷⁰² mutant embryos.

(Shklyar et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^repo/NimC4^UAS.GFP rescues NimC4^KO

(Shklyar et al., 2013)

Comments

Expression of NimC4^{ΔEMI-NIM2.Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^repo rescues the defects in the engulfment of apoptotic neurons seen in the CNS of NimC4^KO mutant embryos.

(Shklyar et al., 2013)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

NimC4^{Scer\UAS.T:Avic\GFP}

NimC4^UAS.GFP

nimC4^{Scer\UAS.T:Avic\GFP}

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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