FB2024_03 , released June 25, 2024
Allele: Dmel\bru1Z2286
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General Information
Symbol
Dmel\bru1Z2286
Species
D. melanogaster
Name
FlyBase ID
FBal0215875
Feature type
allele
Associated gene
Dmel\bru1
Associated Insertion(s)
Carried in Construct
Also Known As
aretz2286
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Sugimura and Lilly, 2006)
Mutagen
ethyl methanesulfonate
(Sugimura and Lilly, 2006)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      germ cell & egg chamber

      (Sugimura and Lilly, 2006)

      germ cell & egg chamber (with Df(2L)esc-P3-0)

      (Sugimura and Lilly, 2006)

      germ cell & egg chamber | supernumerary

      (Sugimura and Lilly, 2006)

      germ cell & egg chamber | supernumerary (with Df(2L)esc-P3-0)

      (Sugimura and Lilly, 2006)

      mitotic spindle | ectopic | oogenesis stage S4 (with bru1PA)

      (Sugimura and Lilly, 2006)

      nurse cell | oogenesis stage S4 (with bru1PA)

      (Sugimura and Lilly, 2006)
      Detailed Description
      Statement
      Reference

      In aretPA/aretZ2286 adult females, oogenesis proceeds normally until stage 4 - meiosis and mitosis of germ cells occurs normally and nurse cells become enlarged an polyploid. But during stage 4, when mitosis of germ cells is over in wild-type, in around 20% of cysts the nurse cells condense their chromosomes and form large mitotic spindles.

      Egg chambers from aretZ2286/aretZ2286 or aretZ2286/Df(2L)esc-P3-0 females contain far greater thean the normal 16 germ cells, and these germ cell fail to become polyploid. Marker analysis suggests that these germ cell fail to exit mitosis at stage wild-type germ cells do.

      (Sugimura and Lilly, 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Koundakijian

      (Sugimura and Lilly, 2006)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      aretZ2286
      (Kanke et al., 2015)
      aretz2286
      (Sugimura and Lilly, 2006)
      bru1Z2286
      Name Synonyms
      Secondary FlyBase IDs
        References (2)