FB2024_03 , released June 25, 2024
Allele: Dmel\vimar09
Open Close
General Information
Symbol
Dmel\vimar09
Species
D. melanogaster
Name
FlyBase ID
FBal0215495
Feature type
allele
Associated gene
Dmel\vimar
Associated Insertion(s)
P{UASp-YFP.Rab8.T22N}vimar09
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{UASp-YFP.Rab8.T22N}vimar09
    Cytology
    Description

    P{UASp-YFP.Rab8.T22N} insertion within vimar.

    (Zhang et al., 2007)
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 1 )
        Disease
        Interaction
        References
        exacerbates  muscular dystrophy
        modeled by DgRNAi.UAS
        (Kucherenko et al., 2011)
        modeled by Dg323
        (Kucherenko et al., 2011)
        modeled by DgO86
        (Kucherenko et al., 2011)
        Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
         

        FlyBase curator comment: Interactions with Dg[086] and/or Dg[323] were detected in a Dg[086]/+ or Dg[323]/+ background which exhibits no obvious changes in muscle morphology. Nonetheless, these interactions have been captured as 'modifier' ('exacerbates') annotations here to best capture the experimental finding and the authors' intention.

        (Kucherenko et al., 2011)
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Enhancer of
        Statement
        Reference

        vimar09/vimar[+] is an enhancer of indirect flight muscle cell phenotype of DgRNAi.UAS, Scer\GAL4Act.PU

        (Kucherenko et al., 2011)
        NOT Enhancer of
        Statement
        Reference

        vimar09/vimar[+] is a non-enhancer of indirect flight muscle cell phenotype of DysRNAi.NH2.UAS, Scer\GAL4Act.PU

        (Kucherenko et al., 2011)
        Other
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        vimar Dys double heterozygous flies (vimar09/Df(3R)Exel6184) do not exhibit indirect flight muscle degeneration.

        vimar09 DgO86 double heterozygous flies exhibit indirect flight muscle degeneration.

        One copy of vimar09 does not enhance the indirect flight muscle degeneration seen when DysdsRNA.NH2.Scer\UAS is expressed under the control of Scer\GAL4Act.PU.

        One copy of vimar09 enhances the indirect flight muscle degeneration seen when DgdsRNA.Scer\UAS is expressed under the control of Scer\GAL4tub.PU.

        vimar09 Dg323 double heterozygous flies exhibit indirect flight muscle degeneration.

        (Kucherenko et al., 2011)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        vimar09
        (Kucherenko et al., 2011)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)